CARGLUMIC ACID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H10N2O5
Molecular Weight	190.154
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

InChIKey=LCQLHJZYVOQKHU-VKHMYHEASA-N

InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022562lbl.pdf | http://www.recordati.com/resources/Pubblicazione/___e5f362471c2c448d873585839d6dd521_/carbaglu-authorized-in-canada.pdf

Carglumic acid is a Carbamoyl Phosphate Synthetase 1 (CPS 1) allosteric modulator. CPS1 is found in the mitochondria and is the first enzyme of the urea cycle, which converts ammonia into urea. Carglumic acid acts as a replacement for NAG in NAGS deficiency patients by activating CPS1 but it does not help to regulate the urea cycle. Carglumic acid under the trade name Carbaglu indicated as adjunctive therapy for the treatment of acute hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). In addition, as maintenance therapy for the treatment of chronic hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carbamoyl-phosphate synthase [ammonia], mitochondrial 2 Target ID: CHEMBL2362990 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21403788	Positive Allosteric Modulator 179

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acute hyperammonemia 1 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022562lbl.pdf	Primary		Approved 8429	CARBAGLU Approved Use Carbaglu (carglumic acid) is a Carbamoyl Phosphate Synthetase 1 (CPS 1) activator indicated as: • Adjunctive therapy for the treatment of acute hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). (1.1) • Maintenance therapy for the treatment of chronic hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). (1.2) Launch Date 2010
Chronic hyperammonemia 1 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022562lbl.pdf	Palliative		Approved 8429	CARBAGLU Approved Use Carbaglu (carglumic acid) is a Carbamoyl Phosphate Synthetase 1 (CPS 1) activator indicated as: • Adjunctive therapy for the treatment of acute hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). (1.1) • Maintenance therapy for the treatment of chronic hyperammonemia due to the deficiency of the hepatic enzyme N-acetylglutamate synthase (NAGS). (1.2) Launch Date 2010

C_max

Value	Dose	Co-administered	Analyte	Population
2892 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25677217/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		CARGLUMIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
2.6 μg/mL REVIEW https://pubmed.ncbi.nlm.nih.gov/30780843/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		CARGLUMIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
23.2 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25677217/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		CARGLUMIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
5.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25677217/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		CARGLUMIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
5.6 h REVIEW https://pubmed.ncbi.nlm.nih.gov/30780843/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:		CARGLUMIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
96.3 mg/kg 2 times / day multiple, oral Recommended Dose: 96.3 mg/kg, 2 times / day Route: oral Route: multiple Dose: 96.3 mg/kg, 2 times / day Sources: https://ojrd.biomedcentral.com/articles/10.1186/s13023-016-0406-2	unhealthy, 5 day n = 21 Health Status: unhealthy Condition: methylmalonic aciduria Age Group: 5 day Sex: M+F Population Size: 21 Sources: https://ojrd.biomedcentral.com/articles/10.1186/s13023-016-0406-2	Sources: https://ojrd.biomedcentral.com/articles/10.1186/s13023-016-0406-2

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737	inhibitor 1767	inhibitor 1852

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 1524 CYP2B6 810 CYP2A6 707 CYP2C8 911 CYP2C19 1478 CYP2E1 882 CYP3A4/5 278	CYP1A 22 CYP2B 10 CYP1A2 1054	CYP1A 56 CYP2B6 547 CYP3A4/5 124

Drug as perpetrator

Target	Modality	Activity
CYP1A 121	inducer 1573 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=38 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 11-12, 38	no
CYP1A2 1692	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2A6 739	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2B6 1001	inducer 1573 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=38 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 11-12, 38	no
CYP2B6 1001	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2C19 1553	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2C8 965	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2C9 1819	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2D6 1891	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP2E1 970	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no
CYP3A4/5 335	inducer 1573 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=38 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 11-12, 38	no
CYP3A4/5 335	inhibitor 3277 Sources: https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_A100_2.pdf#page=23, https://www.pmda.go.jp/drugs/2016/P20161021006/710794000_22800AMX00708_I100_1.pdf#page=12 Page: (PMDA_A100_2 in Japanese) 23, (PMDA_I100_1 in Japanese) 12, 39-42	no

Drug as victim

Target	Modality	Activity
CYP1A 22	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022562s000pharmr.pdf#page=30 Page: 30, 35	no
CYP1A2 1054	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022562s000pharmr.pdf#page=30 Page: 30.0	no
CYP2B 10	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022562s000pharmr.pdf#page=30 Page: 30.0	no
CYP3A4 1737	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022562s000pharmr.pdf#page=30 Page: 30.0	no

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:71028	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:71028
ChemicalBook	CB6183743	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB6183743
MolPort	MolPort-012-207-739	https://www.molport.com/shop/molecule-link/MolPort-012-207-739
ZINC	ZINC000001530283	http://zinc15.docking.org/substances/ZINC000001530283
eMolecules	8294431	https://www.emolecules.com/cgi-bin/more?vid=8294431

PubMed

Title	Date	PubMed
[Orphan drugs and metabolic disorders].	2001 Aug 1-15	11588713
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.	2001 Dec	11738098
Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.	2001 Sep	11518822
N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy.	2002 Dec	12447942
N-carbamylglutamate enhances ammonia detoxification in a patient with decompensated methylmalonic aciduria.	2003 Aug	12948747
Hyperammonaemia as a cause of psychosis in an adolescent.	2003 Nov	12942317
Mammalian N-acetylglutamate synthase.	2004 Apr	15050968
N-carbamylglutamate protects patients with decompensated propionic aciduria from hyperammonaemia.	2005	15877213
Neonatal hyperammonemia: the N-carbamoyl-L-glutamic acid test.	2005 Aug	16126063
Metabolic fates of ammonia-N in ruminal epithelial and duodenal mucosal cells isolated from growing sheep.	2005 Nov	16230702
A trial with N-carbamylglutamate may not detect all patients with NAGS deficiency and neonatal onset.	2007 Jun	17510757
N-carbamylglutamate for neonatal hyperammonaemia in propionic acidaemia.	2008 Dec	18338235
Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?	2008 Jan 30	18234091
N-acetylglutamate synthase: structure, function and defects.	2010	20303810
Outpatient treatment of propionic acidemia-associated hyperammonemia with N-carbamoyl-L-glutamate in an infant.	2010 Apr	20435240
Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet.	2010 Aug	20213438
Gateways to clinical trials.	2010 Dec	21225012
Biochemical efficacy of N-carbamylglutamate in neonatal severe hyperammonaemia due to propionic acidaemia.	2010 Jan	19680687
N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia.	2010 Jul	20566609
Carglumic acid approved to treat genetic hyperammonemia.	2010 May 1	20410539
Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency.	2011	21941437

Patents

Sample Use Guides

In Vivo Use Guide

Adult Dosage: The recommended initial dose for acute hyperammonemia is 100 mg/kg/day to 250 mg/kg/day. Concomitant administration of other ammonia lowering therapies is recommended. Dosing should be titrated based on individual patient plasma ammonia levels and clinical symptoms. The recommended maintenance dose should be titrated to target normal plasma ammonia level for age. Based on limited data in 22 patients receiving maintenance treatment with Carbaglu in a retrospective case series, maintenance doses were usually less than 100 mg/kg/day. The total daily dose should be divided into 2 to 4 doses and rounded to the nearest 100 mg. (i.e. half a Carbaglu Tablet) Pediatric Dosage: The recommended initial dose for acute hyperammonemia is 100 mg/kg/day to 250 mg/kg/day. Concomitant administration of other ammonia lowering therapies is recommended. Dosing should be titrated based on individual patient plasma ammonia levels and clinical symptoms. The recommended maintenance dose should be titrated to target normal plasma ammonia level for age. Based on limited data in 22 patients receiving maintenance treatment with Carbaglu in a retrospective case series, maintenance doses were usually less than 100 mg/kg/day. The total daily dose should be divided into 2 to 4 doses.

Route of Administration: Oral

In Vitro Use Guide

Carglumic acid-treated (1, 5, 10 mM) and untreated cancer cells were stained with propidium iodide to determine DNA contents in the human pancreatic adenocarcinoma cell lines, AsPC1 and human triple-negative breast cancer cell lines MDA-MB-231. The results showed that carglumic acid did not induce complete cell cycle arrest. Instead, we observed more sub-G1 cells among carglumic acid-treated AsPC1 and MDA-MB-231 cells than among untreated cells, indicating that cell death occurred in response to carglumic acid. Sub-G1 cells accounted for 1.6% and 26.3% of untreated and treated AsPC1 cells, respectively , and for 1.8% and 12.8% of untreated and treated MDA-MB-231 cells, respectively. In order to further determine whether cancer cells under go cell death through apoptosis after carglumic acid treatment, we measured caspase activity in AsPC1 cells treated with carglumic acid. The results showed that caspase-3 activity increased in a dose-dependent manner. Together, these data suggest that carglumic acid inhibits cancer cell proliferation by inducing apoptosis.

Name

Type

Language

CARGLUMIC ACID

Official Name

English

CARBAMYL-L-GLUTAMIC ACID

Systematic Name

English

N-CARBAMYL-L-GLUTAMIC ACID

Common Name

English

L-GLUTAMIC ACID, N-(AMINOCARBONYL)-

Common Name

English

CARGLUMIC ACID [JAN]

Common Name

English

CARGLUMIC ACID [EMA EPAR]

Common Name

English

CARGLUMIC ACID [USP-RS]

Common Name

English

CARGLUMIC ACID [ORANGE BOOK]

Common Name

English

CARGLUMIC ACID [MART.]

Common Name

English

Carglumic acid [WHO-DD]

Common Name

English

OE-312

Code

English

NSC-760124

Code

English

OE 312

Code

English

CARGLUMIC ACID [MI]

Common Name

English

carglumic acid [INN]

Common Name

English

N-CARBAMYLGLUTAMATE

Systematic Name

English

CARGLUMIC ACID [VANDF]

Common Name

English

CARGLUMIC ACID [USAN]

Common Name

English

CARBAGLU

Brand Name

English

N-CARBAMOYL-L-GLUTAMIC ACID

Systematic Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

CARBAGLU (AUTHORIZED: AMINO ACID METABOLISM, INBORN ERRORS)

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

FDA ORPHAN DRUG

109997

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

WHO-VATC

QA16AA05

Created by admin on Fri Dec 15 16:34:52 GMT 2023 , Edited by admin on Fri Dec 15 16:34:52 GMT 2023

EU-Orphan Drug

EU/3/00/007

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

NDF-RT

N0000184144

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

WHO-ATC

A16AA05

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

NCI_THESAURUS

C78275

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

FDA ORPHAN DRUG

352111

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

Code System Code Type Description

EPA CompTox

DTXSID7046706

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

MERCK INDEX

m3108

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

Merck Index

SMS_ID

100000089544

Created by admin on Fri Dec 15 16:34:52 GMT 2023 , Edited by admin on Fri Dec 15 16:34:52 GMT 2023

PRIMARY

RS_ITEM_NUM

1096586

Created by admin on Fri Dec 15 16:34:52 GMT 2023 , Edited by admin on Fri Dec 15 16:34:52 GMT 2023

PRIMARY

CAS

1188-38-1

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

EVMPD

SUB20051

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

WIKIPEDIA

CARGLUMIC ACID

Created by admin on Fri Dec 15 16:34:52 GMT 2023 , Edited by admin on Fri Dec 15 16:34:52 GMT 2023

PRIMARY

DAILYMED

5L0HB4V1EW

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

IUPHAR

7458

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

NSC

760124

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

DRUG CENTRAL

3068

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

FDA UNII

5L0HB4V1EW

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

NCI_THESAURUS

C76884

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

USAN

XX-21

Created by admin on Fri Dec 15 16:34:52 GMT 2023 , Edited by admin on Fri Dec 15 16:34:52 GMT 2023

PRIMARY

INN

8008

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

RXCUI

401713

Created by admin on Fri Dec 15 16:34:52 GMT 2023 , Edited by admin on Fri Dec 15 16:34:52 GMT 2023

PRIMARY

RxNorm

PUBCHEM

121396

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

ChEMBL

CHEMBL1201780

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

NDF-RT

N0000184143

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

Carbamoyl Phosphate Synthetase 1 Activators [MoA]

CHEBI

71028

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

DRUG BANK

DB06775

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

PRIMARY

EVMPD

SUB13236MIG

Created by admin on Fri Dec 15 16:34:51 GMT 2023 , Edited by admin on Fri Dec 15 16:34:51 GMT 2023

ALTERNATIVE

ACTIVE MOIETY


					5L0HB4V1EW

CARGLUMIC ACID

Details

SMILES

InChI

DescriptionSources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022562lbl.pdf | http://www.recordati.com/resources/Pubblicazione/___e5f362471c2c448d873585839d6dd521_/carbaglu-authorized-in-canada.pdf

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Approved Use

Launch Date

Cmax

AUC

T1/2

Doses

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022562lbl.pdf | http://www.recordati.com/resources/Pubblicazione/___e5f362471c2c448d873585839d6dd521_/carbaglu-authorized-in-canada.pdf

C_max

T_1/2

Drug as perpetrator