Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | CH3O6P2.3Na |
| Molecular Weight | 241.9478 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[Na+].OP([O-])(=O)CP([O-])([O-])=O
InChI
InChIKey=SFDBJFMMXUVCFG-UHFFFAOYSA-K
InChI=1S/CH6O6P2.3Na/c2-8(3,4)1-9(5,6)7;;;/h1H2,(H2,2,3,4)(H2,5,6,7);;;/q;3*+1/p-3
DescriptionCurator's Comment: Description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=9635
Curator's Comment: Description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=9635
Medronic acid (conjugate base, medronate) is a diagnostic agent that is used in complex with technetium Tc-99m for imaging delineate areas of altered osteogenesis. Upon administration the complex binds to hydroxyapatite crystals in bone.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Hydroxyapatite crystals in bone |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Diagnostic | CIS-MDP Approved UseTechnetium Tc 99m Medronate Injection may be used as a bone imaging agent to delineate areas of altered osteogenesis. Launch Date1979 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cytosolic acidification as a signal mediating hyperosmotic stress responses in Dictyostelium discoideum. | 2001 |
|
| Bone mineral density in multiple myeloma patients after intravenous clodronate therapy. | 2001 |
|
| Prevention of heterotopic ossification after spinal cord injury with indomethacin. | 2001 Jul |
|
| Factors influencing blood flow in the equine digit and their effect on uptake of 99m technetium methylene diphosphonate into bone. | 2001 Nov |
|
| Determination of the casein content in bovine milk by 31P-NMR. | 2002 Aug |
|
| Raynaud phenomenon and Behçet disease: diagnosis with technetium Tc 99m methylene diphosphonate bone scan and treatment with continuous sympathetic block. | 2002 May |
|
| Synthesis of stable analogues of thiamine di- and triphosphate as tools for probing a new phosphorylation pathway. | 2002 Oct 18 |
|
| Aspartyl phosphonates and phosphoramidates: the first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase. | 2002 Sep 2 |
|
| Escherichia coli response to exogenous pyrophosphate and analogs. | 2003 |
|
| Collagen crosslink excretion and staging of oral cancer. | 2003 Apr 7 |
|
| Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. | 2003 Apr 7 |
|
| Infecton: a 99mTc-ciprofloxacin radiopharmaceutical for the detection of bone infection. | 2003 Feb |
|
| Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease. | 2003 Feb 1 |
|
| Effectory site in Escherichia coli inorganic pyrophosphatase is revealed upon mutation at the intertrimeric interface. | 2003 Jan |
|
| Signal enhancement through heteronuclear polarisation transfer in in-vivo 31P MR spectroscopy of the human brain. | 2003 Jul |
|
| Follow-up of collagen crosslink excretion in patients with oral squamous cell carcinoma and analysis of tissue samples. | 2003 Nov 3 |
|
| Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries. | 2003 Oct |
|
| Solid state coordination chemistry: one-, two-, and three-dimensional materials constructed from molybdophosphonate subunits linked through binuclear copper tetra-2-pyridylpyrazine groups. | 2003 Oct 20 |
|
| [A comparison of planar scintigraphy and MRI in the screening of skeletal metastases]. | 2003 Sep |
|
| Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD. | 2004 Apr |
|
| Cervical involvement in juvenile-onset ankylosing spondylitis with bone scintigraphy. | 2004 May |
|
| Calix[4]arene methylenebisphosphonic acids as calf intestine alkaline phosphatase inhibitors. | 2004 Nov 7 |
|
| Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate. | 2004 Oct 4 |
|
| 31P MRS analysis of the phospholipid composition of normal human peripheral blood mononuclear cells (PBMC). | 2005 |
|
| Voltammetry as a virtual potentiometric sensor in modelling of a metal-ligand system and refinement of stability constants. Part 4. An electrochemical study of NiII complexes with methylene diphosphonic acid. | 2005 Dec |
|
| Technetium-99m diphosphonate imaging of psammocarcinoma of probable ovarian origin: case report and literature review. | 2005 Jun |
|
| [A cationic cluster of amino acid residues of inorganic pyrophosphatase from Escherichia coli as a possible site of effector binding]. | 2005 May-Jun |
|
| Biochemical and imaging alterations of renal bone disease in newly detected predialysis and on maintenance dialysis patients. | 2005 Oct |
|
| Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine. | 2006 |
|
| Solitary bone metastasis beneath the shoulder shield: coincidence or cause? | 2006 Aug |
|
| Usefulness of 18F-FDG PET-directed skeletal biopsy for metastatic neoplasm. | 2006 Aug |
|
| Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent. | 2006 Dec |
|
| Use of scintigraphy for diagnosis of equine paranasal sinus disorders. | 2006 Jan |
|
| Characterization of industrial alkylpolyphosphonates by infusion electrospray ionization-ion trap mass spectrometry with identification of the impurities by tandem capillary zone electrophoresis. | 2006 Jan |
|
| Acid resistance of erbium-doped yttrium aluminum garnet laser-treated and phosphoric acid-etched enamels. | 2006 Nov |
|
| Influence of phosphonation and phosphation on surface acid-base and morphological properties of CaO as investigated by in situ FTIR spectroscopy and electron microscopy. | 2006 Nov 1 |
|
| Novel chikungunya virus variant in travelers returning from Indian Ocean islands. | 2006 Oct |
|
| Metastatic pulmonary calcification in a dialysis patient: case report and a review. | 2006 Oct |
|
| Is there a role of whole body bone scan in early stages of non small cell lung cancer patients. | 2006 Oct-Dec |
|
| Nuclear medicine methods for evaluation of skeletal infection among other diagnostic modalities. | 2006 Sep |
|
| Three-level bilateral pediculolysis following osteoporotic lumbar compression fracture. | 2006 Sep-Oct |
|
| Safety considerations with bisphosphonates for the treatment of osteoporosis. | 2007 |
|
| Photo-induced lipid peroxidation of erythrocyte membranes by a bis-methanophosphonate fullerene. | 2007 Dec |
|
| Rapid characterization of alkylpolyphosphonates by CZE with indirect photometric and mass spectrometric detection. | 2007 Feb |
|
| ATP as effector of inorganic pyrophosphatase of Escherichia coli. The role of residue Lys112 in binding effectors. | 2007 Jan |
|
| Binding of substrate at the effector site of pyrophosphatase increases the rate of its hydrolysis at the active site. | 2007 Jan |
|
| Abnormalities in bone mineral density distribution and bone scintigraphy in patients with childhood onset hypopituitarism. | 2007 Jul-Sep |
|
| Ewing's sarcoma of the third metatarsal: a case report and review of the literature. | 2007 Mar-Apr |
|
| Characterization of focal bone lesions in the axial skeleton: performance of planar bone scintigraphy compared with SPECT and SPECT fused with CT. | 2007 May |
|
| Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. | 2007 May |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
39478-93-8
Created by
admin on Sat Dec 16 08:16:42 GMT 2023 , Edited by admin on Sat Dec 16 08:16:42 GMT 2023
|
PRIMARY | |||
|
3352186
Created by
admin on Sat Dec 16 08:16:42 GMT 2023 , Edited by admin on Sat Dec 16 08:16:42 GMT 2023
|
PRIMARY | |||
|
5IE00X21WX
Created by
admin on Sat Dec 16 08:16:42 GMT 2023 , Edited by admin on Sat Dec 16 08:16:42 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD
