MEDRONATE TRISODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	CH3O6P2.3Na
Molecular Weight	241.9478
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[Na+].[Na+].[Na+].OP([O-])(=O)CP([O-])([O-])=O

InChI

InChIKey=SFDBJFMMXUVCFG-UHFFFAOYSA-K

InChI=1S/CH6O6P2.3Na/c2-8(3,4)1-9(5,6)7;;;/h1H2,(H2,2,3,4)(H2,5,6,7);;;/q;3*+1/p-3

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Description

Medronic acid (conjugate base, medronate) is a diagnostic agent that is used in complex with technetium Tc-99m for imaging delineate areas of altered osteogenesis. Upon administration the complex binds to hydroxyapatite crystals in bone.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hydroxyapatite crystals in bone 5	Binding Agent 1,076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Altered osteogenesis 7	Diagnostic		Approved 8,583	CIS-MDP

Doses

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Dose	Population	Adverse events
10000 uCi single, intravenous Recommended	unhealthy	Disc. AE: Allergic rash...
16.5 mg 1 times / day multiple, intravenous	unhealthy	Other AEs: Leukocytopenia, Anemia...

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AEs

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AE	Significance	Dose	Population
Allergic rash	Disc. AE	10000 uCi single, intravenous Recommended	unhealthy
Leukocytopenia	1.7%	16.5 mg 1 times / day multiple, intravenous	unhealthy
Nausea	1.7%	16.5 mg 1 times / day multiple, intravenous	unhealthy
Oral ulceration	1.7%	16.5 mg 1 times / day multiple, intravenous	unhealthy
Elevated liver enzymes	3.4%	16.5 mg 1 times / day multiple, intravenous	unhealthy

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Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1,087	inhibitor 2,438		inhibitor 2,217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
BCRP 910 P-gp 1,741 UMAT 30 CYP19A1 429 CYP2C19 2,057	P-gp 2,052

Drug as perpetrator

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Target	Modality	Activity
BCRP 985	inhibitor 4,027	no
CYP19A1 430	inhibitor 4,027	no
CYP2C19 2,141	inhibitor 4,027	no
CYP2C9 2,497	inhibitor 4,027	no
CYP3A4 2,633	inducer 1,966	no

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Drug as victim

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Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 2,052	substrate 4,014	no

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Tox targets

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Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2,263	inhibitor 2,237

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PubMed

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Title	Date	PubMed
Natural and azido fatty acids inhibit phosphate transport and activate fatty acid anion uniport mediated by the mitochondrial phosphate carrier.	2001 Feb 16	11085992
Determination of the casein content in bovine milk by 31P-NMR.	2002 Aug	12369412
Osteoblast culture on polished titanium disks modified with phosphonic acids.	2002 Oct	12124796
Aspartyl phosphonates and phosphoramidates: the first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase.	2002 Sep 2	12210989
Isoprenoid biosynthesis via the MEP pathway. Synthesis of (3,4)-3,4-dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-D-xylulose 5-phosphate, the substrate of the 1-deoxy-D-xylulose 5-phosphate reducto-isomerase.	2003 Dec 21	14685307

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Patents

Sample Use Guides

In Vivo Use Guide

The suggested dose range of Technetium Tc 99m Medronate Injection in the average adult patient (70 kg) is 370-740 megabecquerels: (10-20 millicuries) given intravenously.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

TRISODIUM MEDRONATE

Preferred Name

English

MEDRONATE TRISODIUM

Common Name

English

TRISODIUM METHYLENEDIPHOSPHONATE

Systematic Name

English

TRISODIUM METHANEDIPHOSPHONATE

Systematic Name

English

PHOSPHONIC ACID, METHYLENEBIS-, TRISODIUM SALT

Systematic Name

English

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Code System

Code

Type

Description

CAS

39478-93-8

PRIMARY

PUBCHEM

3352186

PRIMARY

FDA UNII

5IE00X21WX

PRIMARY

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SUBSTANCE RECORD


					5IE00X21WX

MEDRONATE TRISODIUM

SMILES

InChI

Originator

Approval Year

Targets

Conditions

Doses

AEs

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Tox targets

PubMed

Patents

Sample Use Guides

Drug as perpetrator