Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H44O7 |
| Molecular Weight | 516.6662 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)\C=C\C(C)(C)O
InChI
InChIKey=SRPHMISUTWFFKJ-QJNWWGCFSA-N
InChI=1S/C30H44O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-12,17-20,23,31-32,36-37H,10,13-15H2,1-8H3/b12-11+/t17-,18+,19-,20+,23+,27+,28-,29+,30+/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/27824155
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/27824155
Cucurbitacin D is a plant steroid with anticancer activity. Cucurbitacin D treatment of cervical cancer cells arrested the cell cycle in G1/S phase, inhibited constitutive expression of E6, Cyclin D1, CDK4, pRb, and Rb and induced the protein levels of p21 and p27. Cucurbitacin D also inhibited phosphorylation of STAT3 at Ser727 and Tyr705 residues as well as its downstream target genes c-Myc, and MMP9. In addition, Cucurbitacin D could be used as a useful compound to treat adriamycin-resistant patients with breast carcinoma.
Approval Year
Sample Use Guides
athymic nude mice: 1 mg/kg body weight injected intra-tumorally 3 days a week
Route of Administration:
Other
To determine the effect of Cucurbitacin D on proliferation of cervical cancer cells (CaSki and SiHa), MTS assay was performed. Cucurbitacin D treatment (0.05–1 μM) dose-dependently inhibited viability of cervical cancer cells. IC50 of Cucurbitacin D was 400 nM and 250 nM in CaSki and SiHa cells, respectively, after 72 hrs treatment. 0.5 μM of Cucurbitacin D effectively inhibited invasion of both CaSki and SiHa cells when compared with their respective control groups. Cucurbitacin D also inhibited phosphorylation of STAT3 at Ser727 and Tyr705 residues as well as its downstream target genes c-Myc, and MMP9. Cucurbitacin D enhanced the expression of tumor suppressor microRNAs (miR-145, miRNA-143, and miRNA34a) in cervical cancer cells
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID401032034
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
521776
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
Cucurbitacin D
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
3943
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
5I62H4ORC7
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
5281318
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
3877-86-9
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY | |||
|
308606
Created by
admin on Sat Dec 16 09:14:32 GMT 2023 , Edited by admin on Sat Dec 16 09:14:32 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
