ERIBAXABAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H22ClFN4O4
Molecular Weight	484.907
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@@H]1C[C@@H](N(C1)C(=O)NC2=CC=C(Cl)C=C2)C(=O)NC3=C(F)C=C(C=C3)N4C=CC=CC4=O

InChI

InChIKey=QQBKAVAGLMGMHI-WIYYLYMNSA-N

InChI=1S/C24H22ClFN4O4/c1-34-18-13-21(30(14-18)24(33)27-16-7-5-15(25)6-8-16)23(32)28-20-10-9-17(12-19(20)26)29-11-3-2-4-22(29)31/h2-12,18,21H,13-14H2,1H3,(H,27,33)(H,28,32)/t18-,21-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17683371 | https://adisinsight.springer.com/drugs/800024432 | https://www.ncbi.nlm.nih.gov/pubmed/18096830 | https://www.ncbi.nlm.nih.gov/pubmed/18392334

Eribaxaban (PD 348292) is an orally efficacious factor Xa inhibitor. It demonstrated antithrombotic efficacy in animal models. Pfizer was developing eribaxaban for the treatment of venous thrombosis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Coagulation factor X 20 Target ID: P00742 Gene ID: 2159.0 Gene Symbol: F10 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17683371/ \| https://www.ncbi.nlm.nih.gov/pubmed/26861270	Inhibitor 8297

PubMed

Title	Date	PubMed
Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.	2009	19071881
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.	2009 Mar 15	19231206
Efficacy and toxicity of factor Xa inhibitors.	2013	23683607
An adaptive-design dose-ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery.	2013 Aug	23782955

Patents

Name

Type

Language

ERIBAXABAN

Official Name

English

PD-348292

Code

English

PD-348

Code

English

PD-0348292

Code

English

ERIBAXABAN [USAN]

Common Name

English

PD 348,292

Code

English

Eribaxaban [WHO-DD]

Common Name

English

eribaxaban [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C263