U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C23H32N2O5
Molecular Weight 416.5106
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RAMIPRIL, (-)-

SMILES

[H][C@]12CCC[C@@]1([H])N([C@H](C2)C(O)=O)C(=O)[C@@H](C)N[C@H](CCC3=CC=CC=C3)C(=O)OCC

InChI

InChIKey=HDACQVRGBOVJII-YHUYVZNPSA-N
InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m1/s1

HIDE SMILES / InChI

Description

Ramipril, (-)- is less active R-enantiomer than S-enantiomer. S-ramipril is angiotensin-converting enzyme (ACE) inhibitor, which is used for the treatment of hypertension.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Biosensors for the enantioselective analysis of S-enalapril and S-ramipril.
1998 Nov

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
RAMIPRIL, (-)-
Common Name English
(2R,3AR,6AR)-1-((2R)-2-(((1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)PROPANOYL)OCTAHYDROCYCLOPENTA(B)PYRROLE-2-CARBOXYLIC ACID
Systematic Name English
ENT-RAMIPRIL
Common Name English
ENANTIOMER OF RAMIPRIL
Common Name English
RAMIPRIL IMPURITY J [EP IMPURITY]
Common Name English
Code System Code Type Description
FDA UNII
5COV0OAU1T
Created by admin on Sat Dec 16 08:29:23 GMT 2023 , Edited by admin on Sat Dec 16 08:29:23 GMT 2023
PRIMARY
PUBCHEM
57183875
Created by admin on Sat Dec 16 08:29:23 GMT 2023 , Edited by admin on Sat Dec 16 08:29:23 GMT 2023
PRIMARY
CAS
1246253-05-3
Created by admin on Sat Dec 16 08:29:23 GMT 2023 , Edited by admin on Sat Dec 16 08:29:23 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of RAMIPRIL, (-)-
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966