Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C9H19Cl2N2O5PS2 |
| Molecular Weight | 401.267 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(=O)(=O)CCS[C@H]1CCO[P@@](=O)(N1)N(CCCl)CCCl
InChI
InChIKey=PBUUPFTVAPUWDE-UGZDLDLSSA-N
InChI=1S/C9H19Cl2N2O5PS2/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17/h9H,1-8H2,(H,12,14)(H,15,16,17)/t9-,19-/m0/s1
Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. The effects of mafosfamide on various types of cancer cells were determined during preclinical investigations and clinical trials. Its development has been discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality. | 1996 May 17 |
|
| Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. | 2001 Dec |
Patents
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C697
Created by
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FDA ORPHAN DRUG |
162202
Created by
admin on Fri Dec 15 15:31:34 GMT 2023 , Edited by admin on Fri Dec 15 15:31:34 GMT 2023
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| Code System | Code | Type | Description | ||
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76968809
Created by
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C1150
Created by
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100000081738
Created by
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5518
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CHEMBL59990
Created by
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MAFOSFAMIDE
Created by
admin on Fri Dec 15 15:31:34 GMT 2023 , Edited by admin on Fri Dec 15 15:31:34 GMT 2023
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DB12083
Created by
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DTXSID90905075
Created by
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SUB08635MIG
Created by
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88859-04-5
Created by
admin on Fri Dec 15 15:31:34 GMT 2023 , Edited by admin on Fri Dec 15 15:31:34 GMT 2023
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5970HH9923
Created by
admin on Fri Dec 15 15:31:34 GMT 2023 , Edited by admin on Fri Dec 15 15:31:34 GMT 2023
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C048341
Created by
admin on Fri Dec 15 15:31:34 GMT 2023 , Edited by admin on Fri Dec 15 15:31:34 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
