CYANOCOBALAMIN CO-60

US Previously Marketed

First approved in 1961

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C62H88N13O14P.CN.Co
Molecular Weight	1356.3658
Optical Activity	UNSPECIFIED
Defined Stereocenters	13 / 14
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[60Co+3].[C-]#N.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2[N-]C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@@H]6[C@@H](CO)O[C@@H]([C@@H]6O)N7C=NC8=C7C=C(C)C(C)=C8

InChI

InChIKey=FDJOLVPMNUYSCM-BYCRCCONSA-L

InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56?,57+,59-,60+,61+,62+;;/m1../s1/i;;1+1

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/13519934

Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in the US by unknown reasons.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pernicious anemia 8 Sources: http://www.ncbi.nlm.nih.gov/pubmed/13519934	Diagnostic		Approved 8429	RUBRATOPE-60 Approved Use Unknown Launch Date 6.0393599E10

PubMed

Title	Date	PubMed
Vitamin B12Co60 distribution in dog tissues during many months; red cell stroma with labeled B12 in hemolytic anemia.	1958 Jul 1	13549637
[EFFECTS EXERCISED BY DEPRIVATION OF PROTEINS OR CERTAIN ESSENTIAL AMINO ACIDS ON THE METABOLISM OF CO-60-LABELED VITAMIN B-12 IN THE MALE RAT].	1963	14111662
[ALTERATIONS OF VITAMIN B 12 DUE TO THE EFFECT OF CO-60 GAMMA RADIATIONS].	1965 Jan-Feb	14305520

Sample Use Guides

In Vivo Use Guide

100-200 ug in 2 days (anemia associated with Vitamin B12), 400-500 micrograms in the first 7 days daily, then 1 time every 5-7 days (in anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system).

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

CYANOCOBALAMIN CO-60

Common Name

English

CYANOCOBALAMIN (60CO)

Official Name

English

cyanocobalamin (⁶⁰Co) [INN]

Common Name

English

RACOBALAMIN-60

Code

English

COBALT (60CO) CYANOCOBALAMIN

Common Name

English

CYANOCOBALAMIN CO 60 [USAN]

Common Name

English

RUBRATOPE-60 KIT COMPONENT CYANOCOBALAMIN CO-60

Common Name

English

RUBRATOPE-60

Brand Name

English

CYANOCOBALAMIN CO-60 COMPONENT OF RUBRATOPE-60 KIT

Common Name

English

CYANOCOBALAMIN CO-60 [ORANGE BOOK]

Common Name

English

CYANOCOBALAMIN (60 CO)

Common Name

English

CYANOCOBALAMIN, CO-60

Common Name

English

RADIOACTIVE 60CO VITAMIN B12 [MI]

Common Name

English

CYANOCOBALAMIN CO 60

Official Name

English

VITAMIN B12, CO-60

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124