Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H16F3N3O |
| Molecular Weight | 371.3557 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC=CC(NC(=O)C2=C(NCC3=CC=NC=C3)C=CC=C2)=C1
InChI
InChIKey=BLAFVGLBBOPRLP-UHFFFAOYSA-N
InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
AAL993 (ZK260253) is a potent and selective VEGF receptor kinase (VEGF-R) tyrosine kinase inhibitor (VEGFR2), which binds to an inactive conformation of the protein. In addition, AAL993 possesses dual functions, including suppression of HIF-1 alpha expression through ERK inhibition without affecting Akt phosphorylation.
Approval Year
Sample Use Guides
In Vitro Use Guide
Curator's Comment: AAL993 (AAL-993) possesses dual functions: inhibition of VEGFR signaling and HIF-1alpha expression under the hypoxic condition. The detailed mechanistic study indicated that AAL993 suppressed HIF-1alpha expression through ERK inhibition without affecting Akt phosphorylation.
Unknown
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269390-77-4
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55K5464ZGS
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DTXSID601352234
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6398883
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![Structure of 2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide](/img/918df563-15ad-4162-beac-4a7d66925490.svg "Structure of 2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide")