CLORINDIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H9ClO2
Molecular Weight	256.684
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C2C(=O)C3=C(C=CC=C3)C2=O

InChI

InChIKey=NJDUWAXIURWWLN-UHFFFAOYSA-N

InChI=1S/C15H9ClO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

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Description
Sources: http://www.rxwiki.com/clorindione | https://www.ncbi.nlm.nih.gov/pubmed/4067989 | https://www.ncbi.nlm.nih.gov/pubmed/21313725

Clorindione belongs to a class of drugs which are known to be vitamin K antagonists, and is a derivative of phenindione. It has been demonstrated as effective in reducing prothrombin levels in humans and also to reduce serum cholesterol and triglycerides in mice.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
triglyceride biosynthetic process 1 Target ID: GO:0019432 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4067989	Modulator 846

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypercholesterolemia 51 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4067989	Primary		Not Provided 511	Unknown Approved Use Unknown
Anticoagulant 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21313725	Primary		Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Hypolipidemic activity of indan-1,3-dione derivatives in rodents.	1985-11	4067989
A Trial of Clorindione-A Long Acting Oral Anticoagulant.	1965-12	21313725
[ON THE VALUE OF CHLORPHENYLINDANDIONE IN THE THERAPY OF THROMBOEMBOLISM].	1964-02-29	14153214

Patents

Sample Use Guides

In Vivo Use Guide

32 patients were treated in hospital and administered oral tablets of clorindione; 12 mg on the first day, 8 mg on the second day, and 4 mg on the third day. Because of the delayed action of clorindione, Heparin 10,000 iu was given by intramuscular injection on admission and then 5,000 iu every 6 hours for 3 days at 24-hour intervals. Clorindione effectively reduced the prothrombin levels in the patient population back to the desired therapeutic range by the fourth day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

CLORINDIONE

Official Name

English

CLORINDIONE [MI]

Preferred Name

English

Clorindione [WHO-DD]

Common Name

English

clorindione [INN]

Common Name

English

NSC-758878

Code

English

G-25766

Code

English

2-(P-CHLOROPHENYL)-1,3-INDANDION

Common Name

English

Classification Tree Code System Code

WHO-ATC

B01AA09