Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H18N4O2 |
| Molecular Weight | 286.329 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 2 |
SHOW SMILES / InChI
SMILES
O\N=C\C1=CC=[N+](CCC[N+]2=CC=C(C=C2)\C=N\O)C=C1
InChI
InChIKey=LJYGXPCCGGSATE-UHFFFAOYSA-P
InChI=1S/C15H16N4O2/c20-16-12-14-2-8-18(9-3-14)6-1-7-19-10-4-15(5-11-19)13-17-21/h2-5,8-13H,1,6-7H2/p+2
Trimedoxime is the only one of the major bispyridinium oxime with a propylene linked between the two pyridinium rings. Trimedoxime is an oxime cholinesterase (AChE) reactivator. It was shown that trimedoxime is a more potent reactivator of the DFP-inhibited AChE than pralidoxime and a better reactivator than obidoxime in the case of the tabun-inhibited enzyme. It can be used parenterally as an antidote adjunct to atropine in treating human or animal (organophosphate group) anticholinesterase pesticide toxicity. Trimedoxime was the first oxime that was efficient in the treatment of animals intoxicated with tabun. It could also protect animals poisoned with sarin or VX, but not the ones intoxicated with soman.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Effect of a new cholinesterase reactivator, diethixime, on the central nervous system]. | 1977 Jan |
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| [Noncholinesterase component in the molecular mechanism of action of the cholinesterase reactivator dipyroxime]. | 1982 Jun |
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| Feeding behavior and brain acetylcholinesterase activity in bream (Abramis brama L.) as affected by DDVP, an organophosphorus insecticide. | 1992 Nov |
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| Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo. | 2010 Sep 6 |
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| The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice. | 2010 Sep 6 |
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| Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. | 2014 Feb 28 |
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DTXSID30217705
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6736-02-3
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5969
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Trimedoxime
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53E8JHT760
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927958-99-4
Created by
admin on Sat Dec 16 08:34:44 GMT 2023 , Edited by admin on Sat Dec 16 08:34:44 GMT 2023
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SUPERSEDED |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
