U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C19H32N2O5
Molecular Weight 368.4678
Optical Activity ( + / - )
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1'',3A-DI-EPI-PERINDOPRIL, (±)-

SMILES

[H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@H](CCC)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O

InChI

InChIKey=IPVQLZZIHOAWMC-OTJKEOIZSA-N
InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13+,14+,15-,16-/m0/s1

HIDE SMILES / InChI

Description

(1''R,3AR)-1'',3A-di-epi-Perindopril is an epimer (S, RS, SR) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active than the parent compound, perindopril.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
1'',3A-DI-EPI-PERINDOPRIL, (±)-
Common Name English
PERINDOPRIL TERT-BUTYLAMINE IMPURITY Z [EP IMPURITY]
Common Name English
(±)-1'',3A-DI-EPI-PERINDOPRIL
Common Name English
(2RS,3ASR,7ARS)-1-((2RS)-2-(((1SR)-1-(ETHOXYCARBONYL)BUTYL)AMINO)PROPANOYL)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
Systematic Name English
Code System Code Type Description
FDA UNII
534X2137QC
Created by admin on Sat Dec 16 10:41:55 GMT 2023 , Edited by admin on Sat Dec 16 10:41:55 GMT 2023
PRIMARY
PUBCHEM
9533936
Created by admin on Sat Dec 16 10:41:55 GMT 2023 , Edited by admin on Sat Dec 16 10:41:55 GMT 2023
PRIMARY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966