| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H17ClF3N3O7 |
| Molecular Weight | 527.834 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)N(C(=O)N1CO[C@]2(CC3=C(C=CC(Cl)=C3)C2=N1)C(=O)OC)C4=CC=C(OC(F)(F)F)C=C4
InChI
InChIKey=VBCVPMMZEGZULK-NRFANRHFSA-N
InChI=1S/C22H17ClF3N3O7/c1-33-18(30)21-10-12-9-13(23)3-8-16(12)17(21)27-28(11-35-21)19(31)29(20(32)34-2)14-4-6-15(7-5-14)36-22(24,25)26/h3-9H,10-11H2,1-2H3/t21-/m0/s1
Indoxacarb is a new oxadiazine insecticide discovered and developed by DuPont. The indoxacarb racemate contains two enantiomers (S : R), designated DPX-KN128 and DPX-KN127, but only the S enantiomer has insecticidal activity. It inhibits insect neuronal voltage-dependent sodium channels. Indoxacarb is an active component of Merck Activyl® used in the treatment of flea and tick in dogs and cats. DuPont™ Steward® WG is a water dispersible granule stomach and contact insecticide powered by Indoxacarb for control of various insect pests on a variety of crops.
CNS Activity
Originator
Approval Year
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
Tox targets
PubMed
Patents
Sample Use Guides
Activyl is a spot-on flea treatment for dogs and cats. Active Ingredients
Activyl contains 195 mg of indoxacarb and 354 mg of isopropyl alcohol per mL.
DOGS:
The recommended dose for dogs is 15 - 66 mg indoxacarb/kg bodyweight, equivalent to 0.077 - 0.34 mL/kg bodyweight.
CATS:
The recommended dose for cats is 25 - 166.6 mg indoxacarb/kg bodyweight, equivalent to 0.128 - 0.85 mL/kg bodyweight.
Route of Administration:
Topical
ACTIVE MOIETY
