Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H20N2O2S |
Molecular Weight | 328.4304 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(c1cccc(n1)OC)C(=S)Oc2ccc3CCCCc3c2
InChI
InChIKey=VPHPQNGOVQYUMG-UHFFFAOYSA-N
InChI=1S/C18H20N2O2S/c1-20(16-8-5-9-17(19-16)21-2)18(23)22-15-11-10-13-6-3-4-7-14(13)12-15/h5,8-12H,3-4,6-7H2,1-2H3
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/19194054Curator's Comment:: description was created based on several sources, including
http://jocpr.com/vol5-iss11-2013/JCPR-2013-5-11-219-222.pdf
Sources: http://www.ncbi.nlm.nih.gov/pubmed/19194054
Curator's Comment:: description was created based on several sources, including
http://jocpr.com/vol5-iss11-2013/JCPR-2013-5-11-219-222.pdf
Liranafate (6-methoxy-2-N-methyl-aminopyridine-thiocarboxylic acid-(5,6,7,8 tetrahydro)-β-Naphthyl ester), a new antifungal drug, is synthesis inhibitor of squalene epoxidase inhibitor and cytoderm inhibitor, which was manufactured by Tosoh Corporation and Zenyaku Kogyo Corporation. It firstly came to the market in August 2000 in Japan. By inhibiting the squalene epoxide reactions of fungal cells and detering the synthesis of ergosterol, which is a constituent of cell membrane. The antifungal activity of Liranafate is 8 times as high as that of Tolnaftate. Liranafate is especially effective against trichophyton rubrum.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: Squalene epoxidase fungal |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Unknown Approved UseUnknown |
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Curative | Unknown Approved UseUnknown |
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Curative | Unknown Approved UseUnknown |
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Curative | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: http://pfxbzlx.gdvdc.com/EN/Y2008/V15/I01/12
2% cream applied once a day.
Route of Administration:
Topical
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/19001760
production of IL-8 was profoundly suppressed by the addition of liranaftate to the culture in a dose-dependent manner.
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NCI_THESAURUS |
C514
Created by
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5253IGO5X3
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C66019
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6744
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88678-31-3
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1586
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3936
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C470235
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CHEMBL1591365
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M6840
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SUB08528MIG
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88678-31-3
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ACTIVE MOIETY