U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H19NOS
Molecular Weight 297.415
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLINDATE

SMILES

CN(C(=S)OC1=CC=C2CCCC2=C1)C3=CC(C)=CC=C3

InChI

InChIKey=ANJNOJFLVNXCHT-UHFFFAOYSA-N
InChI=1S/C18H19NOS/c1-13-5-3-8-16(11-13)19(2)18(21)20-17-10-9-14-6-4-7-15(14)12-17/h3,5,8-12H,4,6-7H2,1-2H3

HIDE SMILES / InChI

Description
Curator's Comment: Description was created using several sources including: https://www.google.com/patents/US3509200; http://www.trademarkia.com/dalnate-72412220.html; http://www.druglead.com/cds/tolindate.html; http://jurbase.ru/postr/docum51/part6.htm

Tolindate, a thiocarbamate, is a synthetic antifungal approved by FDA as an over-the-counter (OTC) drug product and is marketed by Norcliff Thayer Inc. It was prepared by treating 5-indanyl thionochloroformate with N-methyl-m-toluidine and patented in 1970 by USV Pharmaceutical Corporation tas a compound with strong topical antifungal activity that may be administered topically in the form of ointments and solutions. It was used in eastern Europe as Dalnate (USV Pharmaceutical Corporation trademark registerd in 6/26/1973) for topical application in the treatment of various dermatoses. Produced by ZORKA Pharma (at present Hemofarm a.d., Serbia) topical cream or solution Dalnate was registered for marketing in Russia.

Originator

Curator's Comment: Was patented in 1970

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
TOLINDATE
INN   MI   USAN  
USAN   INN  
Official Name English
tolindate [INN]
Common Name English
TOLINDATE [USAN]
Common Name English
TOLINDATE [MI]
Common Name English
CARBAMOTHIOIC ACID, METHYL(3-METHYLPHENYL)-, O-(2,3-DIHYDRO-1H-INDEN-5-YL) ESTER
Common Name English
O-5-INDANYL M,N-DIMETHYLTHIOCARBANILATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C514
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
Code System Code Type Description
MERCK INDEX
m10945
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY Merck Index
DRUG CENTRAL
3615
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
CAS
27877-51-6
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID8048818
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
EVMPD
SUB11158MIG
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
FDA UNII
5236RK32KG
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105583
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
PUBCHEM
34051
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
INN
3243
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
SMS_ID
100000077775
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY
NCI_THESAURUS
C84218
Created by admin on Sat Dec 16 18:02:28 GMT 2023 , Edited by admin on Sat Dec 16 18:02:28 GMT 2023
PRIMARY