U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H23NO4
Molecular Weight 341.4009
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THEBACON

SMILES

[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]5([H])CC=C2OC(C)=O

InChI

InChIKey=RRJQTGHQFYTZOW-ILWKUFEGSA-N
InChI=1S/C20H23NO4/c1-11(22)24-16-7-5-13-14-10-12-4-6-15(23-3)18-17(12)20(13,19(16)25-18)8-9-21(14)2/h4,6-7,13-14,19H,5,8-10H2,1-3H3/t13-,14+,19-,20-/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://books.google.ru/books?id=szDnBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.boehringer-ingelheim.us/history/history-milestone/1885-1948 | https://www.ncbi.nlm.nih.gov/pubmed/23440583

Thebacon (dihydrocodeinone enol acetate, trade name Acedicon) is semisynthetic opioid analgetic and antitussive compound. Boehringer-Ingelheim merketed Acedicon for the treatment of cough. Thebacon is a Schedule I drug, that has not got approved use in US.

Originator

Curator's Comment: reference retrived from https://books.google.ru/books?id=_J2ti4EkYpkC&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.boehringer-ingelheim.us/history/history-milestone/1885-1948

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ACEDICON

Approved Use

Antitussive

Launch Date

-1.2939264E12
PubMed

PubMed

TitleDatePubMed
[Acedicon in the symptomatic therapy of pulmonary tuberculosis].
1951 Jan
[Clinical experiences with acedicon tablongettes].
1960 Mar 26
A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats.
2013 Apr
Contribution of human esterases to the metabolism of selected drugs of abuse.
2015 Jan 5
Patents

Patents

Sample Use Guides

In Vitro Use Guide
Unknown
Name Type Language
THEBACON
INN   MI   WHO-DD  
INN  
Official Name English
DIHYDROCODEINONE ENOL ACETATE
Common Name English
IDS-NT-001
Code English
thebacon [INN]
Common Name English
ACETYLDIHYDROCODEINONE
Common Name English
ACETYLDEMETHYLDIHYDROTHEBAINE
Common Name English
Thebacon [WHO-DD]
Common Name English
THEBACON [MI]
Common Name English
NSC-117860
Code English
DEA NO. 9315
Common Name English
MORPHINAN-6-OL, 6,7-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, 6-ACETATE, (5.ALPHA.)-
Systematic Name English
Classification Tree Code System Code
WHO-VATC QR05DA10
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
NCI_THESAURUS C67413
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
WHO-ATC R05DA10
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
DEA NO. 9315
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
Code System Code Type Description
DRUG CENTRAL
3144
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
207-377-2
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
NSC
117860
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
WIKIPEDIA
THEBACON
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
FDA UNII
520D430GDK
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
SMS_ID
100000082744
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
MERCK INDEX
m10696
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY Merck Index
EVMPD
SUB10959MIG
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104751
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
INN
102
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
NCI_THESAURUS
C91052
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
EPA CompTox
DTXSID90891944
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
DRUG BANK
DB13458
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
CAS
466-90-0
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY
PUBCHEM
11508377
Created by admin on Fri Dec 15 17:42:31 UTC 2023 , Edited by admin on Fri Dec 15 17:42:31 UTC 2023
PRIMARY