DOREPTIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H24N4O3
Molecular Weight	332.3975
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@](NC(=O)[C@@H]1CCCN1)(C(=O)NCC(N)=O)C2=CC=CC=C2

InChI

InChIKey=ZALQKBPFOWAOHH-SUMWQHHRSA-N

InChI=1S/C17H24N4O3/c1-2-17(12-7-4-3-5-8-12,16(24)20-11-14(18)22)21-15(23)13-9-6-10-19-13/h3-5,7-8,13,19H,2,6,9-11H2,1H3,(H2,18,22)(H,20,24)(H,21,23)/t13-,17+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1678611 | Milne, G.W.A. (2017) Drugs: Synonyms and Properties, retrieved from: https://books.google.ru/books?id=RlM8DwAAQBAJ

Doreptide is the most active analog of PLG (Pro-Leu-Gly-NH2). It was evaluated as L-dopa potentiating agent for the treatment of Parkinson's disease.

Approval Year

PubMed

Title	Date	PubMed
L-dopa potentiating analogs of Pro-Leu-Gly-NH2 with oral efficacy.	1991-02	1678611

Patents

Name

Type

Language

DOREPTIDE

Official Name

English

(2S)-N-((.ALPHA.R)-.ALPHA.-((CARBAMOYLMETHYL)CARBAMOYL)-.ALPHA.-ETHYLBENZYL)-2-PYRROLIDINECARBOXAMIDE

Preferred Name

English

doreptide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149