SALVIANOLIC ACID A

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H22O10
Molecular Weight	494.4469
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

SMILES

OC(=O)[C@@H](CC1=CC(O)=C(O)C=C1)OC(=O)\C=C\C2=C(/C=C/C3=CC(O)=C(O)C=C3)C(O)=C(O)C=C2

InChI

InChIKey=YMGFTDKNIWPMGF-UCPJVGPRSA-N

InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
Carbonic anhydrase VII 35	Inhibitor 8,504	71.4 nM [Ki]
Carbonic anhydrase XII 30	Inhibitor 8,504	39.8 nM [Ki]
Carbonic anhydrase IV 33	Inhibitor 8,504	66.6 nM [Ki]
Tyrosine-protein kinase SRC 19	Inhibitor 8,504	36.2 µM [IC50]
Tyrosine-protein kinase LCK 14	Inhibitor 8,504	23.5 µM [IC50]

PubMed

PubMed

Show entries

Title	Date	PubMed
Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats.	2007 Feb	17244260
Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis.	2008 May-Jun	18464075
Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats.	2009 Aug 1	19445921
Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats.	2010 Jan 15	19822164
Salvianolic acid A exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice.	2011 Jan	20882408

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Name

Type

Language

(+)-SALVIANOLIC ACID A

Preferred Name

English

SALVIANOLIC ACID A

Common Name

English

BENZENEPROPANOIC ACID, .ALPHA.-((3-(2-(2-(3,4-DIHYDROXYPHENYL)ETHENYL)-3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-3,4-DIHYDROXY-, (R-(E,E))-

Systematic Name

English

DAN PHENOLIC ACID A

Common Name

English

BENZENEPROPANOIC ACID, .ALPHA.-(((2E)-3-(2-((1E)-2-(3,4-DIHYDROXYPHENYL)ETHENYL)-3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-3,4-DIHYDROXY-, (.ALPHA.R)-

Systematic Name

English

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Code System

Code

Type

Description

CAS

96574-01-5

PRIMARY

FDA UNII

51622542XO

PRIMARY

DRUG BANK

DB15246

PRIMARY

PUBCHEM

5281793

PRIMARY

EPA CompTox

DTXSID701316580

PRIMARY

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SUBSTANCE RECORD


					51622542XO

SALVIANOLIC ACID A