SALVIANOLIC ACID A

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H22O10
Molecular Weight	494.4469
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)[C@@H](CC1=CC(O)=C(O)C=C1)OC(=O)\C=C\C2=C(/C=C/C3=CC(O)=C(O)C=C3)C(O)=C(O)C=C2

InChI

InChIKey=YMGFTDKNIWPMGF-UCPJVGPRSA-N

InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Carbonic anhydrase VII 34 Target ID: CHEMBL2326 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26498393	Inhibitor 8297	71.4 nM [Ki]
Carbonic anhydrase XII 30 Target ID: CHEMBL3242 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26498393	Inhibitor 8297	39.8 nM [Ki]
Carbonic anhydrase IV 33 Target ID: CHEMBL3729 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26498393	Inhibitor 8297	66.6 nM [Ki]
Tyrosine-protein kinase SRC 19 Target ID: CHEMBL267 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19427202	Inhibitor 8297	36.2 µM [IC50]
Tyrosine-protein kinase LCK 12 Target ID: CHEMBL258 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19427202	Inhibitor 8297	23.5 µM [IC50]

PubMed

Title	Date	PubMed
Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats.	2007 Feb	17244260
Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats.	2010 Jan 15	19822164
Salvianolic acid A exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice.	2011 Jan	20882408
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.	2013 Nov 15	23993977

Name

Type

Language

SALVIANOLIC ACID A

Common Name

English

BENZENEPROPANOIC ACID, .ALPHA.-((3-(2-(2-(3,4-DIHYDROXYPHENYL)ETHENYL)-3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-3,4-DIHYDROXY-, (R-(E,E))-

Systematic Name

English

(+)-SALVIANOLIC ACID A

Common Name

English

DAN PHENOLIC ACID A

Common Name

English

BENZENEPROPANOIC ACID, .ALPHA.-(((2E)-3-(2-((1E)-2-(3,4-DIHYDROXYPHENYL)ETHENYL)-3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-3,4-DIHYDROXY-, (.ALPHA.R)-

Systematic Name

English

Code System Code Type Description

CAS

96574-01-5