Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H13N5O2 |
| Molecular Weight | 247.2532 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC2=C(N=CN2[C@@H]3C[C@H](CO)C=C3)C(=O)N1
InChI
InChIKey=XSSYCIGJYCVRRK-RQJHMYQMSA-N
InChI=1S/C11H13N5O2/c12-11-14-9-8(10(18)15-11)13-5-16(9)7-2-1-6(3-7)4-17/h1-2,5-7,17H,3-4H2,(H3,12,14,15,18)/t6-,7+/m1/s1
Carbovir is a nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. Carbovir Triphosphate belongs to the class of organic compounds known as nucleoside and nucleotide analogues. These are analogues of nucleosides and nucleotides. Carbovir interferes with the enzyme HIV uses to manufacture new viral particles within an infected cell, and is primarily metabolized to the 5'-triphosphate of Carbovir (CBV-TP) to concentrations sufficient to inhibit HIV reverse transcriptase.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides. | 1990 Jan |
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| Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89. | 1997 May |
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| 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. | 1997 May |
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| Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels. | 2004 Aug 27 |
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| Recent advances in the synthesis of the carbocyclic nucleosides as potential antiviral agents. | 2004 Sep |
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| Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine. | 2005 May |
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| Synthesis and antiviral evaluation of novel 6'(alpha)-methyl-branched Carbovir analogues. | 2005 Sep |
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| Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir. | 2007 Apr 21 |
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| Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells. | 2008 Feb |
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| Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. | 2010 Apr 1 |
|
| Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages. | 2013 Mar |
Patents
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DTXSID50152861
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51560211J4
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120443-30-3
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135433604
Created by
admin on Fri Dec 15 21:20:46 GMT 2023 , Edited by admin on Fri Dec 15 21:20:46 GMT 2023
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SUBSTANCE RECORD
