Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H29IO2 |
Molecular Weight | 416.3368 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)CCCCCCCCC(C)C1=CC=CC=C1I
InChI
InChIKey=IWRUDYQZPTVTPA-UHFFFAOYSA-N
InChI=1S/C19H29IO2/c1-3-22-19(21)15-9-7-5-4-6-8-12-16(2)17-13-10-11-14-18(17)20/h10-11,13-14,16H,3-9,12,15H2,1-2H3
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/22333888Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18312083
http://www.wscj.org/pdf/pdf_WSCJ_74.pdf
https://www.ncbi.nlm.nih.gov/pubmed/3175007
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22333888
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18312083
http://www.wscj.org/pdf/pdf_WSCJ_74.pdf
https://www.ncbi.nlm.nih.gov/pubmed/3175007
Iophendylate (Pantopaque (in USA) or Myodil, formerly manufactures by Glaxo Laboratories (London,UK) was commonly used from the 1940s until the late 1980s for myelography, cisternography, and ventriculography; the use of oil-based contrast agents such as Myodil has been discontinued, and images of intradural oil-based contrast are rarely encountered at present. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected". Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec. Recently was published report, where depicted a unique case of posteriorly located subdural trapped Myodil, about three decades after myelography. The clinical picture of that case highlighted that such a complication didn’t carry the risk of arachnoiditis and could remain silent for several decades. Although Iophendylate is not used for evaluation of spinal disease anymore in the modern diagnostic era, its former use and its intrathecal persistence makes its recognition in MR imaging important. That case emphasized the necessity of awareness about these rare features which continue to present even decades after abandonment of oil-based myelography.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: tumors Sources: https://www.ncbi.nlm.nih.gov/pubmed/22333888 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Diagnostic | PANTOPAQUE Approved UseUnknown Launch Date1943 |
Sample Use Guides
If oily iophendylate was used patient must lie flat for 8 to 12 hours
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3175007
Unknown
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3037234
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C87442
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5153M06QEA
Created by
admin on Fri Dec 15 16:20:35 GMT 2023 , Edited by admin on Fri Dec 15 16:20:35 GMT 2023
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SUBSTANCE RECORD