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Details

Stereochemistry RACEMIC
Molecular Formula C19H29IO2
Molecular Weight 416.3368
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENZENEDECANOIC ACID, 2-IODO-.IOTA.-METHYL-, ETHYL ESTER

SMILES

CCOC(=O)CCCCCCCCC(C)C1=CC=CC=C1I

InChI

InChIKey=IWRUDYQZPTVTPA-UHFFFAOYSA-N
InChI=1S/C19H29IO2/c1-3-22-19(21)15-9-7-5-4-6-8-12-16(2)17-13-10-11-14-18(17)20/h10-11,13-14,16H,3-9,12,15H2,1-2H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18312083 http://www.wscj.org/pdf/pdf_WSCJ_74.pdf https://www.ncbi.nlm.nih.gov/pubmed/3175007

Iophendylate (Pantopaque (in USA) or Myodil, formerly manufactures by Glaxo Laboratories (London,UK) was commonly used from the 1940s until the late 1980s for myelography, cisternography, and ventriculography; the use of oil-based contrast agents such as Myodil has been discontinued, and images of intradural oil-based contrast are rarely encountered at present. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected". Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec. Recently was published report, where depicted a unique case of posteriorly located subdural trapped Myodil, about three decades after myelography. The clinical picture of that case highlighted that such a complication didn’t carry the risk of arachnoiditis and could remain silent for several decades. Although Iophendylate is not used for evaluation of spinal disease anymore in the modern diagnostic era, its former use and its intrathecal persistence makes its recognition in MR imaging important. That case emphasized the necessity of awareness about these rare features which continue to present even decades after abandonment of oil-based myelography.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
PANTOPAQUE

Approved Use

Unknown

Launch Date

1943
PubMed

PubMed

TitleDatePubMed
Iophendylate myelography induced thoracic arachnoiditis, arachnoid cyst and syrinx, four decades later.
2010 Dec
Patents

Patents

Sample Use Guides

If oily iophendylate was used patient must lie flat for 8 to 12 hours
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
BENZENEDECANOIC ACID, 2-IODO-.IOTA.-METHYL-, ETHYL ESTER
Common Name English
ETHYL 10-(2-IODOPHENYL)UNDECANOATE
Systematic Name English
Code System Code Type Description
PUBCHEM
3037234
Created by admin on Fri Dec 15 16:20:35 GMT 2023 , Edited by admin on Fri Dec 15 16:20:35 GMT 2023
PRIMARY
NCI_THESAURUS
C87442
Created by admin on Fri Dec 15 16:20:35 GMT 2023 , Edited by admin on Fri Dec 15 16:20:35 GMT 2023
PRIMARY
FDA UNII
5153M06QEA
Created by admin on Fri Dec 15 16:20:35 GMT 2023 , Edited by admin on Fri Dec 15 16:20:35 GMT 2023
PRIMARY