Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C16H23NO2 |
| Molecular Weight | 261.3593 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(CNC1CCCCC1)OC(=O)C2=CC=CC=C2
InChI
InChIKey=DKLKMKYDWHYZTD-UHFFFAOYSA-N
InChI=1S/C16H23NO2/c1-13(12-17-15-10-6-3-7-11-15)19-16(18)14-8-4-2-5-9-14/h2,4-5,8-9,13,15,17H,3,6-7,10-12H2,1H3
Hexylcaine hydrochloride, a benzoic acid ester, is a local anaesthetic that has been used for surface anaesthesia of mucous membranes. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | CYCLAINE Approved UseHexylcaine hydrochloride, a benzoic acid ester, is a local anaesthetic that has been used for surface anaesthesia of mucous membranes.
Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve. |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
205 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/693515/ |
5 mL single, intrathecal dose: 5 mL route of administration: Intrathecal experiment type: SINGLE co-administered: |
HEXYLCAINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
13 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/693515/ |
5 mL single, intrathecal dose: 5 mL route of administration: Intrathecal experiment type: SINGLE co-administered: |
HEXYLCAINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The clinical use of cyclaine (hexylcaine) as an anesthetic agent in urological surgery: a report of observations of 1000 patients. | 1954 Aug |
|
| NEW AND nonofficial remedies: hexylcaine hydrochloride. | 1954 Jul 3 |
|
| Topical anesthesia with hexylcaine (cyclaine) for major endoscopic procedures; evaluation and comparison in 1,732 administrations. | 1956 Apr 28 |
|
| [Experience in the use of Osmocaine (hexylcaine) as a new local anesthetic in otorhinolaryngology]. | 1961 Nov |
|
| A comparison in rat and mouse heart of the ability of several local anesthetics to inhibit monoamine oxidase. | 1983 |
Patents
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C245
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DB00473
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HEXYLCAINE
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274
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100000083962
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26879
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C004954
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DTXSID1047863
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7196
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532-77-4
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1373
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CHEMBL1197
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SUB08043MIG
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511IU0826Z
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10770
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C65852
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
