Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H16N2O3 |
Molecular Weight | 224.2563 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C)C1(CC=C)C(=O)NC(=O)NC1=O
InChI
InChIKey=BJVVMKUXKQHWJK-UHFFFAOYSA-N
InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)
Talbutal is a short to intermediate-acting barbiturate, which had been used under brand name Latusate as a sedative and hypnotic, but then this usage was discontinued. It was found, that talbutal binds at a distinct binding site at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Thus, the post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2093872 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11264449 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Latusate Approved UseUnknown |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C67084
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WHO-VATC |
QN05CA07
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WHO-ATC |
N05CA07
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DEA NO. |
2100
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m10437
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DTXSID8023630
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CHEMBL1200802
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4YIR8202AX
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89810
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C446080
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3397
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SUB10802MIG
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C66577
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6
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DB00306
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100000083016
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115-44-6
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2556
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8275
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TALBUTAL
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204-090-4
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ACTIVE MOIETY