U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C11H16N2O3
Molecular Weight 224.2563
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TALBUTAL

SMILES

CCC(C)C1(CC=C)C(=O)NC(=O)NC1=O

InChI

InChIKey=BJVVMKUXKQHWJK-UHFFFAOYSA-N
InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)

HIDE SMILES / InChI
Talbutal is a short to intermediate-acting barbiturate, which had been used under brand name Latusate as a sedative and hypnotic, but then this usage was discontinued. It was found, that talbutal binds at a distinct binding site at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Thus, the post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Latusate

Approved Use

Unknown
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
15 h
unknown, unknown
TALBUTAL plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Clinical studies on a new synthetic hypnotic, Win 5095 (lotusate).
1955 Jul
The postoperative use of demerol-lotusate tablets in orthopedic surgery.
1959 Sep
Patents

Sample Use Guides

Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
TALBUTAL
HSDB   INN   MART.   MI   ORANGE BOOK   VANDF   WHO-DD  
INN  
Official Name English
Talbutal [WHO-DD]
Common Name English
5-Allyl-5-sec-butylbarbituric acid
Systematic Name English
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-(1-METHYPROPYL)-5-(2-PROPENYL)-
Common Name English
TALBUTAL [HSDB]
Common Name English
LOTUSATE
Brand Name English
TALBUTAL [MART.]
Common Name English
TALBUTAL [VANDF]
Common Name English
talbutal [INN]
Common Name English
TALBUTAL [MI]
Common Name English
TALBUTAL [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C67084
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
WHO-VATC QN05CA07
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
WHO-ATC N05CA07
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
DEA NO. 2100
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
Code System Code Type Description
MERCK INDEX
m10437
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID8023630
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200802
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
FDA UNII
4YIR8202AX
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
RXCUI
89810
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY RxNorm
MESH
C446080
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
HSDB
3397
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
EVMPD
SUB10802MIG
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
NCI_THESAURUS
C66577
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
INN
6
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
DRUG BANK
DB00306
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
SMS_ID
100000083016
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
CAS
115-44-6
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
DRUG CENTRAL
2556
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
PUBCHEM
8275
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
WIKIPEDIA
TALBUTAL
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
204-090-4
Created by admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
PRIMARY