MERIBENDAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	UNKNOWN
Molecular Formula	C15H14N6O
Molecular Weight	294.3113
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MERIBENDAN

Structure Search

SMILES

CC1CC(=O)NN=C1C2=CC=C3N=C(NC3=C2)C4=NNC=C4

InChI

InChIKey=FDWDHUONLKCDBV-UHFFFAOYSA-N

InChI=1S/C15H14N6O/c1-8-6-13(22)20-21-14(8)9-2-3-10-12(7-9)18-15(17-10)11-4-5-16-19-11/h2-5,7-8H,6H2,1H3,(H,16,19)(H,17,18)(H,20,22)

HIDE SMILES / InChI

Description
Sources: https://www.sciencedirect.com/science/article/pii/022352349390005Y | https://www.ncbi.nlm.nih.gov/pubmed/8996846 | https://www.ncbi.nlm.nih.gov/pubmed/7669483

Meribendan is a phosphodiesterase-III inhibitor. It exerts chrono-inodilatory response.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Differentiation of inodilatory responses by non-invasive measures of cardiovascular performance in healthy man.	1996-12	8996846
Method specificity of the auscultatory estimates of the inodilatory reduction of diastolic blood pressure based on Korotkoff IV and V criteria.	1995-05	7669483

Patents

Patents

Sample Use Guides

In Vivo Use Guide

40 mg

Route of Administration: Oral

Name

Type

Language

meribendan [INN]

Preferred Name

English

MERIBENDAN

Official Name

English

4,5-DIHYDRO-5-METHYL-6-(2-PYRAZOL-3-YL-5-BENZIMIDAZOLYL)-3(2H)-PYRIDAZINONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322

Created by admin on Mon Mar 31 18:37:20 GMT 2025 , Edited by admin on Mon Mar 31 18:37:20 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C83936

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INN

6456

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EVMPD

SUB08776MIG

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CAS

119322-27-9

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EPA CompTox

DTXSID901350813

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SMS_ID

100000081692

Created by admin on Mon Mar 31 18:37:20 GMT 2025 , Edited by admin on Mon Mar 31 18:37:20 GMT 2025

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MESH

C095586

Created by admin on Mon Mar 31 18:37:20 GMT 2025 , Edited by admin on Mon Mar 31 18:37:20 GMT 2025

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FDA UNII

4WYD7I9GF4

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PUBCHEM

65934

Created by admin on Mon Mar 31 18:37:20 GMT 2025 , Edited by admin on Mon Mar 31 18:37:20 GMT 2025

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ChEMBL

CHEMBL85074

Created by admin on Mon Mar 31 18:37:20 GMT 2025 , Edited by admin on Mon Mar 31 18:37:20 GMT 2025

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ACTIVE MOIETY


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