ATILMOTIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C86H134N20O19
Molecular Weight	1752.1068
Optical Activity	UNSPECIFIED
Defined Stereocenters	15 / 15
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@]([H])(NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CC3=CC=CC=C3)[N+](C)(C)C)C(C)C)[C@@H](C)CC)([C@@H](C)O)C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)NCC(=O)N[C@@H](CCC([O-])=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O

InChI

InChIKey=DUQRILZXKXSRIY-RUBJUKRASA-N

InChI=1S/C86H134N20O19/c1-13-51(8)71(103-81(121)65-30-23-41-105(65)85(125)70(50(6)7)102-82(122)66(106(10,11)12)46-54-26-18-15-19-27-54)83(123)101-64(44-53-24-16-14-17-25-53)80(120)104-72(52(9)107)84(124)100-63(45-55-31-33-56(108)34-32-55)74(114)93-47-68(110)94-59(36-38-69(111)112)76(116)99-62(43-49(4)5)79(119)97-60(35-37-67(88)109)77(117)96-58(29-22-40-92-86(90)91)75(115)98-61(42-48(2)3)78(118)95-57(73(89)113)28-20-21-39-87/h14-19,24-27,31-34,48-52,57-66,70-72,107H,13,20-23,28-30,35-47,87H2,1-12H3,(H21-,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124)/t51-,52+,57-,58+,59-,60-,61-,62-,63-,64-,65-,66-,70-,71-,72-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16371080 | https://www.ncbi.nlm.nih.gov/pubmed/19997977

Atilmotin (also known as BAX-ACC-1638), a motilin receptor agonist, is short acting, with t1/2 less than 10 min. It was shown that at doses of 6, 30 or 60 mg intravenously, it affected esophageal, lower esophageal sphincter (LES), and gastric motility. LES and gastric pressures were increased, whereas there was disruption of esophageal peristalsis characterized by lower amplitude and failed contractions. The drug can have the clinical implementation for stomach motility disorders but is needed further study.

Approval Year

PubMed

Title	Date	PubMed
New motilin agonists: a long and winding road.	2006 Jan	16371077
Effect of atilmotin, a motilin receptor agonist, on esophageal, lower esophageal sphincter, and gastric pressures.	2010 Feb	19997977

Sample Use Guides

In Vivo Use Guide

i.v. atilmotin, 6, 30, 60 microg or vehicle (placebo) given 2 min after standardized breakfast, lunch and dinner

Route of Administration: Intravenous

Name

Type

Language

ATILMOTIN

Official Name

English

L-LYSINAMIDE, N-((2S)-1-OXO-3-PHENYL-2-(TRIMETHYLAMMONIO)PROPYL)-L-VALYL-L-PROLYL-L-ISOLEUCYL-L-PHENYLALANYL-L-THREONYL-L-TYROSYLGLYCYL-L-.ALPHA.-GLUTAMYL-L-LEUCYL-L-GLUTAMINYL-D-ARGINYL-L-LEUCYL-

Systematic Name

English

ATILMOTIN [USAN]

Common Name

English

atilmotin [INN]

Common Name

English

BAX-ACC-1638

Code

English

Atilmotin [WHO-DD]

Common Name

English

OHM-11638

Code

English

MOT-288

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C548