KEBUZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H18N2O3
Molecular Weight	322.3578
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=LGYTZKPVOAIUKX-UHFFFAOYSA-N

InChI=1S/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3

HIDE SMILES / InChI

Description
Sources: http://www.pharmazie.com/graphic/A/24/0-13524.pdf

Kebuzone is a cyclooxygenase inhibitor that was used for the treatment of different inflammatory conditions such as thrombophlebitis and rheumatoid arthritis. The current marketing status of the drug is unknown and supposed to be discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase 89 Target ID: CHEMBL2094253 Sources: http://www.pharmazie.com/graphic/A/24/0-13524.pdf	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Thrombophlebitis 3 Sources: http://www.pharmazie.com/graphic/A/24/0-13524.pdf	Palliative		Approved 8429	KETAZON Approved Use Inflammatory and degenerative inflammatory activated forms of rheumatism; rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, neuritis and neuralgia as cervical syndrome, lumbago, sciatica, gout; rheumatism; painful inflammation after injury or surgery; thrombophlebitis.
Musculoskeletal disorders 10 Sources: http://www.pharmazie.com/graphic/A/24/0-13524.pdf	Palliative		Approved 8429	KETAZON Approved Use Inflammatory and degenerative inflammatory activated forms of rheumatism; rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, neuritis and neuralgia as cervical syndrome, lumbago, sciatica, gout; rheumatism; painful inflammation after injury or surgery; thrombophlebitis.

PubMed

Title	Date	PubMed
[Intrahepatic cholestasis following ketazone successfully treated using the enzyme inductor phenobarbital].	1978 Apr	565979
Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.	2001 May-Jun	11386636

Patents

Sample Use Guides

In Vivo Use Guide

1 (250 mg) to 2 dragees 3 times daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

KEBUZONE

Official Name

English

Kebuzone [WHO-DD]

Common Name

English

4-(3-OXOBUTYL)-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE

Systematic Name

English

KEBUZONE [MART.]

Common Name

English

KETOPHENYLBUTAZONE [JAN]

Common Name

English

KETOPHENYLBUTAZONE

Common Name

English

CETOPHENYLBUTAZONE

Common Name

English

kebuzone [INN]

Common Name

English

KEBUZONE [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

M01AA06