ALLETORPHINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H35NO4
Molecular Weight	437.5711
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(CC=C)[C@]([H])(C4)[C@@]56C[C@]([H])([C@](C)(O)CCC)[C@]2(OC)C=C6

InChI

InChIKey=OSQIRUUENNTOQL-PMEKXCSPSA-N

InChI=1S/C27H35NO4/c1-5-9-24(3,30)19-16-25-10-11-27(19,31-4)23-26(25)12-14-28(13-6-2)20(25)15-17-7-8-18(29)22(32-23)21(17)26/h6-8,10-11,19-20,23,29-30H,2,5,9,12-16H2,1,3-4H3/t19-,20-,23-,24-,25-,26+,27-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/766798

Alletorphine (R & S 218-M) is a potent analgesic said to have a reduced respiratory depressant action. It was isolated by Bentley and Hardy (1967) while they were examining a series of derivatives of tetrahydrothebaine of which the potent analgesic etorphine (propylorvinolhydrochloride: M99 Reckitt) is a member. R&S 218-M bears the same relationship to etorphine as does nalorphine to morphine. It has been the subject of experiments in animals and human volunteers.

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

The analgesic effects of Alletorphine (R & S 218-M), administered in doses of 0.56 mg/70 kg and 0.35 mg/70 kg, were compared with those of morphine sulphate 10.5 mg/70 kg for the relief of abdominal pain following surgery in healthy adults. The drugs were given as the first potent analgesic after operation. R & S 218-M 0.56 mg/70 kg was as effective as morphine sulfate 10.5 mg/70 kg, while R & S 218-M 0.35 mg/70 kg was inferior.

Route of Administration: Intramuscular

Name

Type

Language

ALLETORPHINE

Official Name

English

alletorphine [INN]

Common Name

English

17-ALLYL-17-DEMETHYL-7.ALPHA.-((R)-1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHENOTETRAHYDROORIPAVINE

Common Name

English

N-ALLYLNORETORPHINE

Common Name

English

R&S-218M

Code

English

R&S 218-M

Code

English

R&S-218-M

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C67413