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Details

Stereochemistry ACHIRAL
Molecular Formula C15H15ClN2O4S
Molecular Weight 354.809
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of XIPAMIDE

SMILES

CC1=CC=CC(C)=C1NC(=O)C2=C(O)C=C(Cl)C(=C2)S(N)(=O)=O

InChI

InChIKey=MTZBBNMLMNBNJL-UHFFFAOYSA-N
InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)

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Description

Xipamide is a diuretic of thiazide class. It is used for the treatment of hypertension and edema. The diuretic effect of the drug is due to reduction of sodium reabsorption and increase in potassium excretion.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DIUREXAN
Primary
DIUREXAN

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Oedema, initially 40 mg daily by mouth, subsequently reduced to 20 mg daily according to response. Hypertension, 20 mg daily as a single morning dose, either alone or  with other antihypertensives.
Route of Administration: Oral
In Vitro Use Guide
The in vitro effects of xipamide in a concentration range of 10(-8) to 10(-2) M were investigated on various Na+ and K+ transport systems in human red blood cells. Xipamide inhibited the anion carrier or DIDS-sensitive LiCO3- -influx starting from a concentration of 10(-5) M.