| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H5NO2 |
| Molecular Weight | 75.0666 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)NO
InChI
InChIKey=RRUDCFGSUDOHDG-UHFFFAOYSA-N
InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
Acetohydroxamic acid (also known as AHA or by the trade name Lithostat) is a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic acid is used to lower the level of ammonia in the urine, which may help with some types of urinary infections. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. In 1983 the US Food and Drug Administration approved acetohydroxamic acid (AHA) as an orphan drug for "prevention of so-called struvite stones" under the newly enacted Orphan Drug Act of 1983.
Originator
Approval Year
Doses
AEs
Sample Use Guides
Usual Adult Dose for Urinary Tract Infection
Starting dose: 12 mg/kg/day administered at 6 to 8 hour intervals at a time when the stomach is empty.
Then progress to one tablet orally 3 to 4 times a day in a total daily dose of 10 to 15 mg/kg/day.
The maximum daily dose should be no more than 1.5 grams, regardless of body weight.
Route of Administration:
Oral
ACTIVE MOIETY
