U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C9H7INO3.Na
Molecular Weight 323.0521
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODOHIPPURATE SODIUM I-123

SMILES

[Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1[123I]

InChI

InChIKey=XYITYKDGJLHYPW-TWDNZPFZSA-M
InChI=1S/C9H8INO3.Na/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13;/h1-4H,5H2,(H,11,14)(H,12,13);/q;+1/p-1/i10-4;

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6485965 | https://www.ncbi.nlm.nih.gov/pubmed/6492475 | https://www.ncbi.nlm.nih.gov/pubmed/3680968 | https://www.ncbi.nlm.nih.gov/pubmed/2208882 | https://www.ncbi.nlm.nih.gov/pubmed/8767955 | https://www.ncbi.nlm.nih.gov/pubmed/8827809 | https://www.ncbi.nlm.nih.gov/pubmed/6677098

I-123 radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. It has been used to evaluate renal functioning in patients with obstructive uropathy, vesicorenal reflux, hypertensiion due to renal artery stenosis.

Approval Year

1984
110
Targets

Targets

Primary TargetPharmacologyConditionPotency
Interacts
323
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Withdrawn
IODOHIPPURATE SODIUM I-123

Approved Use

Unknown

Launch Date

1984
PubMed

PubMed

TitleDatePubMed
Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits.
2000-09
Modification of measurement of effective renal plasma flow from blood pool clearance curve of I-123-orthoiodohippurate using single blood sampling.
1998-11-14
Measurement of effective renal plasma flow (ERPF) with 123I-orthoiodohippurate (I-123-OIH).
1996-05-01
[Mean renal transit time of I-123 orthoiodohippurate in normotensive and hypertensive subjects].
1996-01-01
Comparison of scintigraphic renal differentials using radiolabeled orthoiodohippurate and glucoheptonate.
1991-06
Diminished response to furosemide in I-123 Hippuran renal studies of renovascular hypertension caused by unilateral renal artery stenosis.
1990-09
[The course of renal function in vesicorenal reflux. Study using I-123 Hippuran].
1987
A simplified method for the routine determination of effective renal plasma flow.
1986-11
[Age and sex dependence of tubular kidney clearance in childhood].
1984-10-25
[Dynamic urinary flow images in patients with ileal loop diversion assessed by I-123-hippuran scintigraphy. Detection of ileoureteral reflux].
1984-06
[Regional renogram and functional imaging with I-123-orthoiodohippurate in obstructive nephropathy].
1983-11
Posture-induced disturbance of pertechnetate flow and I-123 iodohippurate transport in some renal graft recipients with hypertension.
1980-09
Renal clearance and extraction parameters of ortho-iodohippurate (I-123) compared with OIH(I-131) and PAH.
1980-02
Patents

Patents

US4883650
2
US4942231
2
US8188296
2

Sample Use Guides

In Vivo Use Guide
After 1 mCi of I-123- orthoiodohippurate was given intravenously, serial renal scintigrams were obtained for 25 minutes and regional renogram curves were derived from the whole kidney, the cortical and pelvic areas.
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
IODOHIPPURATE SODIUM I 123
USAN   USP  
USAN  
Preferred Name English
IODOHIPPURATE SODIUM I-123
ORANGE BOOK  
Common Name English
GLYCINE, N-(2-(IODO-(SUP 123)I) BENZOYL)-, MONOSODIUM SALT
Common Name English
O-IODOHIPPURATE SODIUM 123I-LABELED FORM [MI]
Common Name English
IODOHIPPURATE SODIUM I-123 [ORANGE BOOK]
Common Name English
SODIUM IODOHIPPURATE (123 I)
WHO-DD  
Common Name English
IODOHIPPURATE SODIUM I 123 [USP IMPURITY]
Common Name English
IODOHIPPURATE SODIUM, I-123
Common Name English
Sodium iodohippurate (123 i) [WHO-DD]
Common Name English
IODOHIPPURATE SODIUM I 123 [USAN]
Common Name English
SODIUM IODOHIPPURATE (123-I)
Common Name English
IODOHIPPURATE SODIUM,I-123 [VANDF]
Common Name English
O-IODOHIPPURATE SODIUM 123I-LABELED FORM
MI  
Common Name English
IODOHIPPURATE SODIUM,I-123
VANDF  
Common Name English
IODOHIPPURATE I123 SODIUM
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2124
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
WHO-VATC QV09CX01
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
Code System Code Type Description
SMS_ID
100000084951
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
FDA UNII
4NW20GFQ7H
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
MERCK INDEX
m6347
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID60204805
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
RXCUI
91551
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY RxNorm
CAS
56254-07-0
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
NCI_THESAURUS
C76279
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
ChEMBL
CHEMBL1681
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
PUBCHEM
23667636
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
LACTMED
Iodohippurate Sodium I 123
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
EVMPD
SUB04458MIG
Created by admin on Mon Mar 31 17:54:54 GMT 2025 , Edited by admin on Mon Mar 31 17:54:54 GMT 2025
PRIMARY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966