SATRANIDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H11N5O5S
Molecular Weight	289.268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=NC=C1[N+]([O-])=O)N2CCN(C2=O)S(C)(=O)=O

InChI

InChIKey=FNSHYEAUAUHIMB-UHFFFAOYSA-N

InChI=1S/C8H11N5O5S/c1-10-6(13(15)16)5-9-7(10)11-3-4-12(8(11)14)19(2,17)18/h5H,3-4H2,1-2H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17103040 | https://www.ncbi.nlm.nih.gov/pubmed/26748382 | https://www.ncbi.nlm.nih.gov/pubmed/26242010

Satranidazole is a drug that helps to combat a large number of varied health disorders effectively. This drug participated in clinical trials in patients of amebic liver abscess, where it showed a far lower incidence of side effects and had a significantly better tolerance than metronidazole. Besides, satranidazole has been studied an adjunct to scaling and root planning in the treatment of chronic periodontitis. satranidazole has a low polar surface area, high dose, and dosing frequency. Nanosizing with appropriate stabilizers and programmed processing conditions successfully produced SAT-NC with improved pharmaceutic and pharmacokinetic characteristics.

Approval Year

PubMed

Title	Date	PubMed
Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.	2006 Dec	17103040
Determination and evaluation of solubility parameter of satranidazole using dioxane-water system.	2010 Sep	21695009

Sample Use Guides

In Vivo Use Guide

Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtime).

Route of Administration: Oral

Name

Type

Language

SATRANIDAZOLE

Official Name

English

Satranidazole [WHO-DD]

Common Name

English

satranidazole [INN]

Common Name

English

SATRANIDAZOLE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277