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Details

Stereochemistry ACHIRAL
Molecular Formula C20H21NO5
Molecular Weight 355.3844
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of REPIRINAST

SMILES

CC(C)CCOC(=O)C1=CC(=O)C2=C(O1)C3=CC=C(C)C(C)=C3NC2=O

InChI

InChIKey=NFQIAEMCQGTTIR-UHFFFAOYSA-N
InChI=1S/C20H21NO5/c1-10(2)7-8-25-20(24)15-9-14(22)16-18(26-15)13-6-5-11(3)12(4)17(13)21-19(16)23/h5-6,9-10H,7-8H2,1-4H3,(H,21,23)

HIDE SMILES / InChI

Description

Repirinast is an antiallergic drug developed and introduced into the market in Japan in 1987. It is a histamine release inhibitor. It has demonstrated effectiveness for treating bronchial asthma in humans.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
100.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Romet

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
For the treatment of atopic asthma - 300 mg twice daily for 7 days
Route of Administration: Oral
In Vitro Use Guide
Formations of leukotriene B4 by neutrophils activated with a calcium ionophore (A23187) were effectively inhibited at concentrations 20-200 uM.