Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H6O3.C3H4N2 |
Molecular Weight | 206.198 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N1C=CN=C1.OC(=O)C2=CC=CC=C2O
InChI
InChIKey=XCHHJFVNQPPLJK-UHFFFAOYSA-N
InChI=1S/C7H6O3.C3H4N2/c8-6-4-2-1-3-5(6)7(9)10;1-2-5-3-4-1/h1-4,8H,(H,9,10);1-3H,(H,4,5)
Imidazole salicylate (also known as ITF-182), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits Tromboxane A2 synthesis, without interfering with cyclo-oxygenase pathway and possesses the limited inhibitory effects on prostaglandin synthesis. Imidazole salicylate can be used for the treatment of osteoarthrosis and musculoskeletal trauma. In addition, it can be given to patients with decompensated cirrhosis without risk of inhibiting kidney prostaglandin synthesis. Imidazole salicylate was characterized by good gastric tolerability and could be assigned for treatment of rheumatic diseases in the elderly. The drug also can be safely used in aspirin-sensitive patients.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2071268
Imidazole salicylate (750 mg t.i.d.) was compared with ibuprofen (400 mg t.i.d.) in a 60-day double-blind parallel group clinical trial in 31 patients with osteoarthritis
Route of Administration:
Oral
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WHO-ATC |
N02BA16
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NCI_THESAURUS |
C257
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WHO-VATC |
QN02BA16
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CHEMBL2104788
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DB13860
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36364-49-5
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37425
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C043292
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C65894
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SUB08145MIG
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4JVD4X01MJ
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m6224
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Imidazole salicylate
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100000083937
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5485
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27438
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DTXSID80189887
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD