U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O3.C3H4N2
Molecular Weight 206.198
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMIDAZOLE SALICYLATE

SMILES

N1C=CN=C1.OC(=O)C2=CC=CC=C2O

InChI

InChIKey=XCHHJFVNQPPLJK-UHFFFAOYSA-N
InChI=1S/C7H6O3.C3H4N2/c8-6-4-2-1-3-5(6)7(9)10;1-2-5-3-4-1/h1-4,8H,(H,9,10);1-3H,(H,4,5)

HIDE SMILES / InChI
Imidazole salicylate (also known as ITF-182), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits Tromboxane A2 synthesis, without interfering with cyclo-oxygenase pathway and possesses the limited inhibitory effects on prostaglandin synthesis. Imidazole salicylate can be used for the treatment of osteoarthrosis and musculoskeletal trauma. In addition, it can be given to patients with decompensated cirrhosis without risk of inhibiting kidney prostaglandin synthesis. Imidazole salicylate was characterized by good gastric tolerability and could be assigned for treatment of rheumatic diseases in the elderly. The drug also can be safely used in aspirin-sensitive patients.

Approval Year

PubMed

PubMed

TitleDatePubMed
Imidazole salicylate in the treatment of osteoarthrosis and musculoskeletal trauma: a postmarketing survey.
1988
Double-blind randomized clinical trial on imidazole salicylate vs ibuprofen in osteoarthritis.
1991 May

Sample Use Guides

Imidazole salicylate (750 mg t.i.d.) was compared with ibuprofen (400 mg t.i.d.) in a 60-day double-blind parallel group clinical trial in 31 patients with osteoarthritis
Route of Administration: Oral
Name Type Language
IMIDAZOLE SALICYLATE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
IMIDAZOLE SALICYLATE [MART.]
Common Name English
imidazole salicylate [INN]
Common Name English
IMIDAZOLE-2-HYDROXYBENZOATE
Systematic Name English
Imidazole salicylate [WHO-DD]
Common Name English
IMIDAZOLE SALICYLATE [MI]
Common Name English
SALICYLIC ACID, COMPOUND WITH IMIDAZOLE (1:1)
Common Name English
SELEZEN
Brand Name English
Classification Tree Code System Code
WHO-ATC N02BA16
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
NCI_THESAURUS C257
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
WHO-VATC QN02BA16
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2104788
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
DRUG BANK
DB13860
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
CAS
36364-49-5
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
PUBCHEM
37425
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
MESH
C043292
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
NCI_THESAURUS
C65894
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
EVMPD
SUB08145MIG
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
FDA UNII
4JVD4X01MJ
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
MERCK INDEX
m6224
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Imidazole salicylate
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
SMS_ID
100000083937
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
INN
5485
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY
RXCUI
27438
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID80189887
Created by admin on Fri Dec 15 16:22:01 GMT 2023 , Edited by admin on Fri Dec 15 16:22:01 GMT 2023
PRIMARY