PELANSERIN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H24N4O2.ClH
Molecular Weight	400.902
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C1NC2=C(C=CC=C2)C(=O)N1CCCN3CCN(CC3)C4=CC=CC=C4

InChI

InChIKey=SXZRLCAHCIRKJU-UHFFFAOYSA-N

InChI=1S/C21H24N4O2.ClH/c26-20-18-9-4-5-10-19(18)22-21(27)25(20)12-6-11-23-13-15-24(16-14-23)17-7-2-1-3-8-17;/h1-5,7-10H,6,11-16H2,(H,22,27);1H

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7493607 | https://www.ncbi.nlm.nih.gov/pubmed/1445477 | https://adisinsight.springer.com/drugs/800001361

Pelanserin is an antagonist of the serotonin 5-HT2 receptor and blocks alpha 1-adrenoceptor. Experiments on dogs have revealed that pelanserin showed adequate pharmacokinetic and pharmacodynamics profiles as an antihypertensive agent that is why the drug possessed potential therapeutic usefulness in the treatment of hypertension. Pelanserin was undergoing phase II clinical trials by Cinvestav in Mexico; however, these studied were discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2 (5-HT2) receptor 90 Target ID: CHEMBL2095200 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6494139 \| https://www.ncbi.nlm.nih.gov/pubmed/7493607	Antagonist 2849
Adrenergic receptor alpha-1 171 Target ID: CHEMBL2094251 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7493607	Antagonist 2849

PubMed

Title	Date	PubMed
Carbopol 934-Sodium Alginate-Gelatin Mucoadhesive Ondansetron Tablets for Buccal Delivery: Effect of pH Modifiers.	2010-07	21218058
Influence of Organic Acids on Diltiazem HCl Release Kinetics from Hydroxypropyl Methyl Cellulose Matrix Tablets.	2010-07	21042476
Alkylation of 2,4-(1H,3H)-quinazolinediones with dialkyl carbonates under microwave irradiations.	2009-05-20	19471206
Mechanism of the antihypertensive effect of TR2515, a potent serotonin antagonist.	1984	6494139

Name

Type

Language

PELANSERIN HYDROCHLORIDE

Official Name

English

TR-2515

Preferred Name

English

PELANSERIN HYDROCHLORIDE [USAN]

Common Name

English

PELANSERIN HCL

Common Name

English

3-[3-(4-Phenyl-1-piperazinyl)propyl]-2,4(1H,3H)-quinazolinedione monohydrochloride

Systematic Name

English

2,4(1H,3H)-QUINAZOLINEDIONE, 3-(3-(4-PHENYL-1-PIPERAZINYL)PROPYL)-, MONOHYDROCHLORIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885