Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H24F3NO5S |
| Molecular Weight | 411.436 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN([C@@H]1[C@@H](O)C(C)(C)OC2=CC=C(OCCCC(F)(F)F)C=C12)S(C)(=O)=O
InChI
InChIKey=SRZRLJWUQFIZRH-LSDHHAIUSA-N
InChI=1S/C17H24F3NO5S/c1-16(2)15(22)14(21(3)27(4,23)24)12-10-11(6-7-13(12)26-16)25-9-5-8-17(18,19)20/h6-7,10,14-15,22H,5,8-9H2,1-4H3/t14-,15+/m0/s1
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11689069 | https://www.ncbi.nlm.nih.gov/pubmed/15795798
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11689069 | https://www.ncbi.nlm.nih.gov/pubmed/15795798
HMR 1556 is a blocker of the slow component of the delayed rectifier potassium current (IKs). It is being preclinically developed by sanofi-aventis in Germany as an oral agent for the treatment of atrial fibrillation.
Originator
Approval Year
Sample Use Guides
Pigs: HMR 1556 (30 mg/kg, p.o., 10 days) efficiently and safely restores sinus rhythm and prevents heart failure in a model of persistent atrial fibrillation.
Rabbit: HMR 1556 (1 mg/kg/hr i.v.).
Route of Administration:
Other
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223749-46-0
Created by
admin on Fri Dec 15 16:42:36 GMT 2023 , Edited by admin on Fri Dec 15 16:42:36 GMT 2023
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4IF4R31066
Created by
admin on Fri Dec 15 16:42:36 GMT 2023 , Edited by admin on Fri Dec 15 16:42:36 GMT 2023
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DTXSID801105017
Created by
admin on Fri Dec 15 16:42:36 GMT 2023 , Edited by admin on Fri Dec 15 16:42:36 GMT 2023
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9887834
Created by
admin on Fri Dec 15 16:42:36 GMT 2023 , Edited by admin on Fri Dec 15 16:42:36 GMT 2023
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ACTIVE MOIETY
