NIPECOTIC ACID, SODIUM SALT

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H10NO2.Na
Molecular Weight	151.1389
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NIPECOTIC ACID, SODIUM SALT

SMILES

[Na+].[O-]C(=O)C1CCCNC1

InChI

InChIKey=JWURTSBVSVTIRC-UHFFFAOYSA-M

InChI=1S/C6H11NO2.Na/c8-6(9)5-2-1-3-7-4-5;/h5,7H,1-4H2,(H,8,9);/q;+1/p-1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
GABA transporter 1 8	Inhibitor 8,297	8.0 µM [IC50]
GABA transporter 2 3	Inhibitor 8,297	38.0 µM [IC50]
GABA transporter 3 6	Inhibitor 8,297	106.0 µM [IC50]

PubMed

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Title	Date	PubMed
Tiagabine in clinical practice.	2001	11520322
GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.	2001 Apr	11287477
Transport of L-carnitine in isolated cerebral cortex neurons.	2001 Apr	11277932
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.	2001 Apr 1	11276050
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.	2001 Nov	11597457

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Patents

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Name

Type

Language

NIPECOTIC ACID, SODIUM SALT

Common Name

English

NSC-62908

Code

English

3-PIPERIDINECARBOXYLIC ACID, SODIUM SALT

Systematic Name

English

3-PIPERIDINECARBOXYLIC ACID, MONOSODIUM SALT

Systematic Name

English

Showing 1 to 4 of 4 entries

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Code System

Code

Type

Description

PUBCHEM

23719484

PRIMARY

NSC

62908

PRIMARY

CAS

89799-21-3

PRIMARY

FDA UNII

4FFB4R29DS

PRIMARY

Showing 1 to 4 of 4 entries

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PARENT (SALT/SOLVATE)


					1U1QTN40SY

NIPECOTIC ACID

SUBSTANCE RECORD


					4FFB4R29DS

NIPECOTIC ACID, SODIUM SALT