U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry MIXED
Molecular Formula C12H22O6
Molecular Weight 262.2995
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETOGLUCID

SMILES

C(COCCOCC1CO1)OCCOCC2CO2

InChI

InChIKey=UMILHIMHKXVDGH-UHFFFAOYSA-N
InChI=1S/C12H22O6/c1(13-3-5-15-7-11-9-17-11)2-14-4-6-16-8-12-10-18-12/h11-12H,1-10H2

HIDE SMILES / InChI
Etoglucid is a cytotoxic drug used as neoplastic agent for the treatment of malignant tumors. Etoglucid was synthesized by reacting a diol with two equivalents of an alkyl chloride. This alkylating agent is commonly used in Europe but is not available in the United States. It is readily diffusible into the cerebral fluid into cerebrospinal fluid but has a metabolic half-life of only 10 to 15 min. It has been shown in animal experiments to be rapidly destroyed in the liver and thus possibly less damaging to the bone-marrow. Only the polymorphonuclear leucocytes being greatly reduced. The blood returned to normal in two to three weeks, and no other important toxic changes were observed.

Approval Year

Sample Use Guides

75 to 100 mg/kg of body weight
Route of Administration: Intra-arterial
Name Type Language
ETOGLUCID
INN   MART.   MI   WHO-DD  
INN  
Official Name English
NSC-80439
Code English
etoglucid [INN]
Common Name English
ICI-32865
Code English
ETHOGLUCID
Common Name English
ETOGLUCID [MART.]
Common Name English
ICI 32865
Code English
ETOGLUCID [MI]
Common Name English
Etoglucid [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC L01AG01
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
NCI_THESAURUS C1590
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
WHO-VATC QL01AG01
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
Code System Code Type Description
MESH
D005009
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
NCI_THESAURUS
C489
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
SMS_ID
100000082105
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
EPA CompTox
DTXSID80862800
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
DRUG CENTRAL
3213
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
RXCUI
4132
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY RxNorm
NSC
80439
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
INN
1579
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
EVMPD
SUB07326MIG
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
WIKIPEDIA
Etoglucid
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
CAS
1954-28-5
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
PUBCHEM
16058
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
ChEMBL
CHEMBL460287
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
MERCK INDEX
m5195
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY Merck Index
FDA UNII
4F9KUA0T4D
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
ECHA (EC/EINECS)
217-784-7
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY
DRUG BANK
DB13339
Created by admin on Fri Dec 15 16:17:35 GMT 2023 , Edited by admin on Fri Dec 15 16:17:35 GMT 2023
PRIMARY