Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H30N2O4.2C4H6O6 |
| Molecular Weight | 698.669 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@@]12OC3=C4C(C[C@@]5([H])N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OCCN6CCOCC6
InChI
InChIKey=GZJIYWTVLNYQGH-MNNIXRQBSA-N
InChI=1S/C23H30N2O4.2C4H6O6/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25;2*5-1(3(7)8)2(6)4(9)10/h2-5,16-18,22,26H,6-14H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t16-,17+,18-,22-,23-;2*1-,2-/m011/s1
DescriptionCurator's Comment: Description was created based on several sources, including http://www.phadia.com/Global/ImmunoCAP%20Allergens/Product%20Leaflets/Product_Leaflet_c261_Pholcodine.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23773349
Curator's Comment: Description was created based on several sources, including http://www.phadia.com/Global/ImmunoCAP%20Allergens/Product%20Leaflets/Product_Leaflet_c261_Pholcodine.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23773349
Pholcodine is an opioid that has been widely used worldwide since 1950 for the treatment of non-productive cough in children and adults. Illicit drug.
Additionally Pholcodine is a marker for sensitization to neuromuscular blocking agents (NMBA) and is intended for use as a diagnostic tool in NMBA-induced anaphylaxis.
CNS Activity
Originator
Sources: Chabrier, P., Guidicelli, R. & Thuillier, J. (1950) Etude chimique, pharmacologique et clinique d’un nouveau skdatif de la toux: la morpholyethyimorphine (M.E.M.). Annales Pharmaceutiques Francais. 8, 26 1-273.
Curator's Comment: Reference was retrieved from: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.1988.tb00502.x/epdf
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P33535|||Q64064 Gene ID: 25601.0 Gene Symbol: Oprm1 Target Organism: Rattus norvegicus (Rat) |
|||
Target ID: P35372|||G8XRH8|||Q5TDA1|||Q9UN57 Gene ID: 4988.0 Gene Symbol: OPRM1 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Pholcodine Linctus B.P. Approved UseCough |
|||
| Diagnostic | ImmunoCAP® Allergen c261 Approved UseAnaphylaxis to neuromuscular blocking agents |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Interpretation of GC-MS opiate results in the presence of pholcodine. | 2002 Jun 25 |
|
| Prevalence of IgE antibodies to morphine. Relation to the high and low incidences of NMBA anaphylaxis in Norway and Sweden, respectively. | 2005 Apr |
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| Automated multiple development thin-layer chromatography for separation of opiate alkaloids and derivatives. | 2005 Jul 8 |
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| Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography/electron impact mass spectrometry. | 2005 Jun |
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| Immunoglobulin E antibodies to rocuronium: a new diagnostic tool. | 2007 Aug |
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| Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents. | 2007 Dec |
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| Hypersensitivity reactions to neuromuscular blocking agents. | 2008 |
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| Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period. | 2008 Jun |
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| Pholcodine caused anaphylaxis in Sweden 30 years ago. | 2009 May |
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| [Anaphylaxis during anaesthesia]. | 2010 Mar 11 |
|
| Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. | 2010 Oct 6 |
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7369-11-1
Created by
admin on Sat Dec 16 10:44:18 GMT 2023 , Edited by admin on Sat Dec 16 10:44:18 GMT 2023
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NON-SPECIFIC STOICHIOMETRY | |||
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4F1CY0O7OD
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admin on Sat Dec 16 10:44:18 GMT 2023 , Edited by admin on Sat Dec 16 10:44:18 GMT 2023
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124107-36-4
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admin on Sat Dec 16 10:44:18 GMT 2023 , Edited by admin on Sat Dec 16 10:44:18 GMT 2023
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86278259
Created by
admin on Sat Dec 16 10:44:18 GMT 2023 , Edited by admin on Sat Dec 16 10:44:18 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD
