NOXYTIOLIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H8N2OS
Molecular Weight	120.173
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=S)NCO

InChI

InChIKey=JLMHZVYLAQPMOZ-UHFFFAOYSA-N

InChI=1S/C3H8N2OS/c1-4-3(7)5-2-6/h6H,2H2,1H3,(H2,4,5,7)

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Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3142635
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/3142634 | http://www.ncbi.nlm.nih.gov/pubmed/3097078 | http://www.ncbi.nlm.nih.gov/pubmed/35068 | http://www.ncbi.nlm.nih.gov/pubmed/5835451

Noxythiolin is an antimicrobial agent. It can be used for irrigation procedures with noxythiolin solution to reduce the risk of sepsis in patients undergoing percutaneous drainage procedures. It seems mechanism of action is based on ability of noxythiolin to decompose in solution to liberate most of its formaldehyde.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
thyroid hormone generation 1 Target ID: GO:0006590 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2060892	Inhibitor 8504	9.0 µM [IC50]
Pathogenic Escherichia coli infection 1 Target ID: map05130 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2904994	Inhibitor 8504
Staphylococcus aureus infection 1 Target ID: map05150 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2904994	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Empyema 2 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6795589	Preventing		Basic research	Unknown Approved Use Unknown
Peritonitis 22 Sources: http://www.ncbi.nlm.nih.gov/pubmed/35068	Preventing		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Activity of disinfectants against Gram-negative bacilli isolated from patients undergoing lung transplantation for cystic fibrosis.	2002-11	12431498
Comparative studies on the effect of noxythiolin and other thioureas on the thyroid using in vitro and in vivo models of thyroid function.	1991-05	2060892
The activity of locally applied cytotoxics to breast cancer cells in vitro.	1991-03	1708217
In-vitro antibacterial activity of noxythiolin and taurolidine.	1990-08	1981591
[Adjuvant treatment of tubal surgery. Randomized prospective study of systemically administered corticoids and noxythiolin].	1989	2515220
Sustained anti-adherence activity of taurolidine (Taurolin) and noxythiolin (Noxyflex S) solutions.	1988-07	2904994
Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations.	1986-10	3097078
Inhibition of hyphal development and kill of Candida albicans blastospores by noxythiolin in vitro.	1986-04	3087931
An investigation of the in vitro anti-bacterial activity of noxythiolin against 1,000 pathogenic bacterial isolates.	1986-04	3086387
A comparison of noxythiolin and povidone-iodine in experimentally induced peritoneal infection in mice.	1978-09	359084
Release of formaldehyde from polynoxylin and noxythiolin.	1965-09	5835451

Patents

Sample Use Guides

In Vivo Use Guide

1-2.5 % solution

Route of Administration: Irrigation

In Vitro Use Guide

Noxythiolin (Noxyflex-S) inhibited iodide organification (thyroid hormone synthesis) by cultured porcine thyrocytes in vitro after 5 hr (IC50 approx. 9.0 microM)

Name

Type

Language

NOXYTIOLIN

Official Name

English

NOXYTHIOLIN

Preferred Name

English

Noxytiolin [WHO-DD]

Common Name

English

NOXYTIOLIN [MART.]

Common Name

English

1-HYDROXYMETHYL-3-METHYL-2-THIOUREA

Systematic Name

English

noxytiolin [INN]

Common Name

English

NOXYTHIOLIN [MI]

Common Name

English

NOXYFLEX

Brand Name

English

Classification Tree Code System Code

WHO-ATC

B05CA07