NIVIMEDONE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H8NO4.Na.H2O
Molecular Weight	259.1906
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.[Na+].CC1=C(C)C=C2C(=O)C(C(=O)C2=C1)=[N+]([O-])[O-]

InChI

InChIKey=CCVFYFVABDKJST-UHFFFAOYSA-N

InChI=1S/C11H8NO4.Na.H2O/c1-5-3-7-8(4-6(5)2)11(14)9(10(7)13)12(15)16;;/h3-4H,1-2H3;;1H2/q-1;+1;

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/121884 | https://www.ncbi.nlm.nih.gov/pubmed/415988

Sodium nivimedone (BRL10833) is an orally administered anti-allergic agent with similar properties to DSCG. Nivimedone inhibited IgE-mediated passive cutaneous anaphylactic (PCA) reactions in the rat and the antigen-induced release of histamine from human lung passively sensitized with atopic serum. The pharmacological potency of sodium nivimedone when compared to DSCG was 42 times greater in the human lung system and approximately ten times greater in rat PCA. In addition, single doses of sodium nivimedone given by mouth inhibited antigen-induced bronchoconstriction in man.

Approval Year

PubMed

Title	Date	PubMed
Peritoneal anaphylaxis in the rat after sensitization with mouse antiserum.	1978	415988
The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils.	1979 Jul	121884

Sample Use Guides

In Vivo Use Guide

Sodium nivimedone (BRL10833) given at an oral dose of 200 mg thrice daily, was compared, after a preliminary standardization week, with placebo in a 6-week double-blind cross-over trial.

Route of Administration: Oral

In Vitro Use Guide

Nivimedone (BRL10833) increases cAMP at a relatively high dose (10(-4) M) in guinea pig ileum.

Name

Type

Language

NIVIMEDONE SODIUM

Official Name

English

1H-INDENE-1,3(2H)-DIONE, 5,6-DIMETHYL-2-NITRO-, ION(1-), SODIUM, MONOHYDRATE

Common Name

English

NIVIMEDONE SODIUM [USAN]

Common Name

English

5,6-Dimethyl-2-aci-nitro-1,3-indandione sodium salt, monohydrate

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29714