GSK-2881078

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H13F3N2O2S
Molecular Weight	330.325
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of GSK-2881078

Structure Search

SMILES

C[C@H](CS(C)(=O)=O)N1C=CC2=C1C=CC(C#N)=C2C(F)(F)F

InChI

InChIKey=SKDVMPZQJMZEAC-SECBINFHSA-N

InChI=1S/C14H13F3N2O2S/c1-9(8-22(2,20)21)19-6-5-11-12(19)4-3-10(7-18)13(11)14(15,16)17/h3-6,9H,8H2,1-2H3/t9-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Androgen receptor 42 Target ID: P10275 Gene ID: 367.0 Gene Symbol: AR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28449232	Modulator 828
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30825507 \| https://www.ncbi.nlm.nih.gov/pubmed/29982690	Modulator 828		3.99 nM [EC50]

Name

Type

Language

GSK-2881078

Code

English

2881078

Code

English

1H-INDOLE-5-CARBONITRILE, 1-((1R)-1-METHYL-2-(METHYLSULFONYL)ETHYL)-4-(TRIFLUOROMETHYL)-

Systematic Name

English

(R)-1-(1-(METHYLSULFONYL)PROPAN-2-YL)-4-(TRIFLUOROMETHYL)-1H-INDOLE-5-CARBONITRILE

Systematic Name

English

Code System Code Type Description

FDA UNII

47M5ZXU844

Created by admin on Sat Dec 16 08:09:30 GMT 2023 , Edited by admin on Sat Dec 16 08:09:30 GMT 2023

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ChEMBL

CHEMBL3545174

Created by admin on Sat Dec 16 08:09:30 GMT 2023 , Edited by admin on Sat Dec 16 08:09:30 GMT 2023

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CAS

1539314-06-1

Created by admin on Sat Dec 16 08:09:30 GMT 2023 , Edited by admin on Sat Dec 16 08:09:30 GMT 2023

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EPA CompTox

DTXSID701337261

Created by admin on Sat Dec 16 08:09:30 GMT 2023 , Edited by admin on Sat Dec 16 08:09:30 GMT 2023

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MANUFACTURER PRODUCT INFORMATION

GSK-2881078

Created by admin on Sat Dec 16 08:09:30 GMT 2023 , Edited by admin on Sat Dec 16 08:09:30 GMT 2023

PRIMARY

MedKoo CAT NO.: 526708, CAS NO.: 1539314-06-1Description: GSK-2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia. GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function. (last updated: 6/24/2016).

PUBCHEM

86709174

Created by admin on Sat Dec 16 08:09:30 GMT 2023 , Edited by admin on Sat Dec 16 08:09:30 GMT 2023

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ACTIVE MOIETY


					47M5ZXU844