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Details

Stereochemistry ACHIRAL
Molecular Formula C11H11NO4S
Molecular Weight 253.274
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACTINOQUINOL

SMILES

CCOC1=CC=C(C2=CC=CN=C12)S(O)(=O)=O

InChI

InChIKey=YAMVZYRZAMBCED-UHFFFAOYSA-N
InChI=1S/C11H11NO4S/c1-2-16-9-5-6-10(17(13,14)15)8-4-3-7-12-11(8)9/h3-7H,2H2,1H3,(H,13,14,15)

HIDE SMILES / InChI

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/22480421 | https://www.ncbi.nlm.nih.gov/pubmed/23075132

Actinoquinol is sunscreen agent that absorbs Ultraviolet B light. Actinoquinol in combination with hyaluronic acid drops might be helpful for the human eye in the defense against photooxidative and other oxidative processes.

Originator

Sources: Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1932), 5, 803-8.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
The effect of actinoquinol with hyaluronic acid in eye drops on the optical properties and oxidative damage of the rabbit cornea irradiated with UVB rays.
2010 Nov-Dec
Patents

Patents

Sample Use Guides

The sterile buffered solution of 0.2 % actinoquinol with 0.15 % hyaluronic acid, pH 7.2 was dropped on the right eye (one drop every 30 s, five drops in total)
Route of Administration: Topical
The inhibition of EBV-EA activation was assayed using the EBV genome carrying lymphoblastoid Raji cells of human origin, which were cultivated in RPMI 1640 medium. The cells were incubated at 370 C for 48 h in 1 mL of the medium containing butyric acid (4 mM, as co-inducer), TPA (20 ng/mL, 32 pM) and a known amount of Actinoquinol in DMSO. Smears were made from cell suspension. The EBV-EA-expressing cells were stained with high titre EBV-EA-positive serum from nasopharyngeal carcinoma patients and detected by an indirect immunofluorescence technique. In each assay, 500 cells were counted, and the experiments were carried out in triplicate. The average EA induction was compared to that of a positive control experiment with butyric acid (4 mM) and TPA (32 pM).
Name Type Language
ACTINOQUINOL
INN   MI   WHO-DD  
INN  
Official Name English
ACTINOQUINOL [MI]
Common Name English
8-ETHOXY-5-QUINOLINESULFONIC ACID
Systematic Name English
NSC-165584
Code English
Actinoquinol [WHO-DD]
Common Name English
actinoquinol [INN]
Common Name English
5-QUINOLINESULFONIC ACID, 8-ETHOXY-
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 17:17:22 GMT 2023 , Edited by admin on Fri Dec 15 17:17:22 GMT 2023
Code System Code Type Description
WIKIPEDIA
Actinoquinol
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MERCK INDEX
m5
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PRIMARY Merck Index
DRUG CENTRAL
3664
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CAS
15301-40-3
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NSC
165584
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NCI_THESAURUS
C76254
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EVMPD
SUB05256MIG
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ChEMBL
CHEMBL1356732
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SMS_ID
100000087695
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PUBCHEM
23674
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EPA CompTox
DTXSID4046521
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FDA UNII
470VQE23O3
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ECHA (EC/EINECS)
239-334-9
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MESH
C556636
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INN
1626
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