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Details

Stereochemistry RACEMIC
Molecular Formula C19H17ClN2O4
Molecular Weight 372.802
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLAFENINE

SMILES

OCC(O)COC(=O)C1=CC=CC=C1NC2=C3C=CC(Cl)=CC3=NC=C2

InChI

InChIKey=GWOFUCIGLDBNKM-UHFFFAOYSA-N
InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)

HIDE SMILES / InChI

Description

Glafenine is a non-steroidal anti-inflammatory drug (NSAID). Glafenine was withdrawn due to the risk of anaphylaxis and acute kidney failure.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Secondary
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
200-400 mg, 3-4 times per day
Route of Administration: Oral
In Vitro Use Guide
human aortic smooth muscle cells (haSMCs) and human endothelial cells (ECs) were seeded in tissue culture flasks. The cells were treated for 4 days with glafenine hydrochloride (10 uM, 50 uM, 100 uM). Half of the treated groups were incubated again with glafenine hydrochloride, the other half received medium free of glafenine hydrochloride every 4 days until day 20.