ROLICYPRINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H16N2O2
Molecular Weight	244.289
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]1(CCC(=O)N1)C(=O)N[C@@H]2C[C@H]2C3=CC=CC=C3

InChI

InChIKey=UGSLDMJXBQKDCT-SDDRHHMPSA-N

InChI=1S/C14H16N2O2/c17-13-7-6-11(15-13)14(18)16-12-8-10(12)9-4-2-1-3-5-9/h1-5,10-12H,6-8H2,(H,15,17)(H,16,18)/t10-,11-,12+/m0/s1

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Description
Sources: http://www.druglead.com/cds/Rolicyprine.html | https://www.sciencedirect.com/science/article/pii/0014299973902057

Rolicyprine (EX-4883) is an antidepressant. This compound is a potent inhibitor of monoamine oxidase in vivo. One study found that rolicyprine must be biotransformed before it is a pharmacologically active compound. Once it is activated, Rolicyprine appears to have a pharmacology like that of the antidepressant tranylcypromine. It was suggested that the products of this biotransformation are tranylcypromine and pyrrolidone carboxylic acid. No information on current use of rolicyprine is available.

Approval Year

Name

Type

Language

ROLICYPRINE

Official Name

English

ROLICYPRINE [USAN]

Common Name

English

RMI-83027

Code

English

ROLICYPRINE [MI]

Common Name

English

EX 4883

Code

English

EX-4883

Code

English

L-TRANS-(+)-5-OXO-N-(2-PHENYLCYCLOPROPYL)-2-PYRROLIDINECARBOXAMIDE

Common Name

English

CYPROMIN

Brand Name

English

RMI 83,027

Code

English

ROLICYPRAM

Common Name

English

rolicyprine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667