U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N2O4
Molecular Weight 156.0963
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NIFUROXIME

SMILES

O\N=C/C1=CC=C(O1)[N+]([O-])=O

InChI

InChIKey=PTBKFATYSVLSSD-UTCJRWHESA-N
InChI=1S/C5H4N2O4/c8-6-3-4-1-2-5(11-4)7(9)10/h1-3,8H/b6-3-

HIDE SMILES / InChI

Description

Nifuroxime is anti-infective agent used in protozoal & fungal infections. The combination of furazolidone and nifuroxime in vaginal suppositories and vaginal insufflation powder was found to be an effective trichomonacidal compound. Nifuroxime was marketed under the brand name Nifurat, Nifurat consists of Attapulgite and Nifuroxime. Nifurat is an oral, nonabsorbed medication that is used in the management of diarrhea. It works by adsorbing (binding) large numbers of bacteria and toxins and reducing the loss of water. Nifurat reduces the number of bowel movements, improves the consistency of loose or watery stools, and relieves the gastrointestinal cramping that often is associated with diarrhea. Used for: Nifurat is used for the short-term treatment of diarrhea. Nifuroxime is proposed as a radiosensitizing agent with solid tumors.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
680.0 nM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Nifurat
Curative
MICOFUR

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
The patient is instructed to insert a suppository high into the vagina each morning and night.
Route of Administration: Vaginal
In Vitro Use Guide
Maximal sensitization with only moderate toxicity was expected when spheroids were exposed to a concentration of 1 mM nifuroxime for 2 hours .