U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N2O4
Molecular Weight 156.0963
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NIFUROXIME

SMILES

O\N=C/C1=CC=C(O1)[N+]([O-])=O

InChI

InChIKey=PTBKFATYSVLSSD-UTCJRWHESA-N
InChI=1S/C5H4N2O4/c8-6-3-4-1-2-5(11-4)7(9)10/h1-3,8H/b6-3-

HIDE SMILES / InChI
Nifuroxime is anti-infective agent used in protozoal & fungal infections. The combination of furazolidone and nifuroxime in vaginal suppositories and vaginal insufflation powder was found to be an effective trichomonacidal compound. Nifuroxime was marketed under the brand name Nifurat, Nifurat consists of Attapulgite and Nifuroxime. Nifurat is an oral, nonabsorbed medication that is used in the management of diarrhea. It works by adsorbing (binding) large numbers of bacteria and toxins and reducing the loss of water. Nifurat reduces the number of bowel movements, improves the consistency of loose or watery stools, and relieves the gastrointestinal cramping that often is associated with diarrhea. Used for: Nifurat is used for the short-term treatment of diarrhea. Nifuroxime is proposed as a radiosensitizing agent with solid tumors.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
680.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Nifurat

Approved Use

Nifurat is used for the short-term treatment of diarrhea.
Curative
MICOFUR

Approved Use

Trichomonas vaginitis

Launch Date

-3.95452809E11
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

The patient is instructed to insert a suppository high into the vagina each morning and night.
Route of Administration: Vaginal
In Vitro Use Guide
Curator's Comment: The ability of nifuroxime to sensitize hypoxic cells in spheroids of Chinese-hamster V79-171B lung cells was tested.
Maximal sensitization with only moderate toxicity was expected when spheroids were exposed to a concentration of 1 mM nifuroxime for 2 hours .
Name Type Language
NIFUROXIME
GREEN BOOK   INN   MART.   MI   WHO-DD  
INN  
Official Name English
2-FURANCARBOXALDEHYDE, 5-NITRO-, OXIME, (C(Z))-
Systematic Name English
ANTI-5-NITRO-2-FURALDOXIME
Common Name English
NSC-662
Code English
5-NITRO-2-FURALDEHYDE OXIME
Systematic Name English
Nifuroxime [WHO-DD]
Common Name English
NIFUROXIME [GREEN BOOK]
Common Name English
nifuroxime [INN]
Common Name English
NIFUROXIME [MART.]
Common Name English
NIFUROXIME [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
Code System Code Type Description
INN
1002
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
SMS_ID
100000083874
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
MESH
C073332
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
MERCK INDEX
m7890
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C77053
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
FDA UNII
465N7P5U85
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
DRUG CENTRAL
3381
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
EPA CompTox
DTXSID8046402
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
ChEMBL
CHEMBL15721
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
NSC
662
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
CAS
6236-05-1
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
EVMPD
SUB09272MIG
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
ECHA (EC/EINECS)
228-349-6
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY
PUBCHEM
5373493
Created by admin on Fri Dec 15 15:13:11 UTC 2023 , Edited by admin on Fri Dec 15 15:13:11 UTC 2023
PRIMARY