U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C27H33F3N4O3
Molecular Weight 518.5711
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIRAMETOSTAT

SMILES

COC1=C(CNC(=O)C2=C(C)N([C@H](C)C3CCN(CC(F)(F)F)CC3)C4=CC=CC=C24)C(=O)NC(C)=C1

InChI

InChIKey=HPODOLXTMDHLLC-QGZVFWFLSA-N
InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Name Type Language
LIRAMETOSTAT
INN  
Official Name English
(R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL-1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMIDE
Systematic Name English
CPI-1205
Code English
lirametostat [INN]
Common Name English
EZH2 INHIBITOR CPI-1205
Common Name English
Lirametostat [WHO-DD]
Common Name English
1H-INDOLE-3-CARBOXAMIDE, N-((1,2-DIHYDRO-4-METHOXY-6-METHYL-2-OXO-3-PYRIDINYL)METHYL)-2-METHYL-1-((1R)-1-(1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL)ETHYL)-
Systematic Name English
Code System Code Type Description
DRUG BANK
DB14581
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
INN
11381
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
NCI_THESAURUS
C121639
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
FDA UNII
455J2479FY
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
PUBCHEM
78320408
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
SMS_ID
300000027497
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
CAS
1621862-70-1
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
PRIMARY
CAS
1450656-11-7
Created by admin on Sat Dec 16 10:47:16 GMT 2023 , Edited by admin on Sat Dec 16 10:47:16 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY