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Details

Stereochemistry RACEMIC
Molecular Formula C21H28N2O5S
Molecular Weight 420.522
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIENOXOLOL

SMILES

CCOC(=O)C1=C(OCC(O)CNC(C)(C)C)C=CC(NC(=O)C2=CC=CS2)=C1

InChI

InChIKey=PHMRLCQEIQGCHH-UHFFFAOYSA-N
InChI=1S/C21H28N2O5S/c1-5-27-20(26)16-11-14(23-19(25)18-7-6-10-29-18)8-9-17(16)28-13-15(24)12-22-21(2,3)4/h6-11,15,22,24H,5,12-13H2,1-4H3,(H,23,25)

HIDE SMILES / InChI
Tienoxolol is a benzoic acid derivative patented by Centre d'Activite et de Recherche Pharmaceutique Industrielle Biologique et Medicale as β-sympatholytic and diuretic. Tienoxolol acts as a beta-adrenergic receptor antagonist shows potent diuretic and natriuretic activity and, besides that anti-hypertension activity in preclinical models. In clinical trials, Tienoxolol significantly and dose-dependently reduced exercise-induced tachycardia. This effect started 1 h after drug administration, peaked between 4 h and 6 h and lasted at least 12 h.

Approval Year

PubMed

PubMed

TitleDatePubMed
Evaluation of the natriuretic and beta-adrenoceptor-blocking effects of tienoxolol in normal volunteers.
1988
Analytical profile of the new diuretic beta-blocking agent tienoxolol hydrochloride.
1988 May
Patents

Patents

Sample Use Guides

150 mg and 300 mg
Route of Administration: Oral
Name Type Language
TIENOXOLOL
INN  
INN  
Official Name English
tienoxolol [INN]
Common Name English
(±)-ETHYL 2-(3-(TERT-BUTYLAMINO)-2-HYDROXYPROPOXY)-5-(2-THIOPHENECARBOXAMIDO)BENZOATE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29576
Created by admin on Fri Dec 15 15:50:03 GMT 2023 , Edited by admin on Fri Dec 15 15:50:03 GMT 2023
Code System Code Type Description
EVMPD
SUB11035MIG
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SMS_ID
100000082190
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MESH
C056983
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WIKIPEDIA
Tienoxolol
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PUBCHEM
65678
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NCI_THESAURUS
C90801
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ChEMBL
CHEMBL8148
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INN
5986
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CAS
90055-97-3
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EPA CompTox
DTXSID50869043
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FDA UNII
44MR81YQ9R
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