PHENACTROPINIUM CHLORIDE

US Previously Marketed

First approved in 1961

Details

Stereochemistry	EPIMERIC
Molecular Formula	C24H28NO4.Cl
Molecular Weight	429.936
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].C[N+]2(CC(=O)C1=CC=CC=C1)[C@H]3CC[C@@H]2C[C@@H](C3)OC(=O)C(O)C4=CC=CC=C4

InChI

InChIKey=NMWOUJTUPILZRV-PVPIFILRSA-M

InChI=1S/C24H28NO4.ClH/c1-25(16-22(26)17-8-4-2-5-9-17)19-12-13-20(25)15-21(14-19)29-24(28)23(27)18-10-6-3-7-11-18;/h2-11,19-21,23,27H,12-16H2,1H3;1H/q+1;/p-1/t19-,20+,21+,23?,25?;

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13460131 | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2044.1961.tb13376.x

PHENACTROPINIUM (TROPHENIUM®), a tropinium ester, is an agent for the production of controlled hypotension during general anesthesia, providing ganglion blockade without direct vasodilator action.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14014486 http://www.drugfuture.com/chemdata/Phenactropinium-Chloride.html	Primary		Approved 8583	Trophenium Approved Use Antihypertensive Launch Date 1960

Sourcing

Vendor/Aggregator	ID	URL
BOC Sciences	3784-89-2
ChEMBL	CHEMBL2111125
ChemIDplus	697214894	https://chem.nlm.nih.gov/chemidplus/id/0697214894
Tetrahedron	TS81930
Wikidata	Q27262617
ZINC	ZINC000261506652	http://zinc15.docking.org/substances/ZINC000261506652
ZINC	ZINC000261506653	http://zinc15.docking.org/substances/ZINC000261506653
ZINC	ZINC000261506654	http://zinc15.docking.org/substances/ZINC000261506654
ZINC	ZINC000261506655	http://zinc15.docking.org/substances/ZINC000261506655

PubMed

Title	Date	PubMed
Phenactropinium chloride; clinical observations.	1961-01	13697724
The use of fluothane and trophenium in anaesthesia for the surgery of deafness.	1958-12	13624747
The use of a homatropinium derivative to produce controlled hypotension.	1957-08	13460131

Patents

Name

Type

Language

ROQ-432

Preferred Name

English

PHENACTROPINIUM CHLORIDE

Official Name

English

phenactropinium chloride [INN]

Common Name

English

PHENACTROPINIUM CHLORIDE [MI]

Common Name

English

8-AZONIABICYCLO(3.2.1)OCTANE, 3-((2-HYDROXY-2-PHENYLACETYL)OXY)-8-METHYL-8-(2-OXO-2-PHENYLETHYL)-, CHLORIDE (1:1)

Systematic Name

English

N-PHENACYLHOMATROPINIUM CHLORIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66886