Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C16H19N3O5S.2H2O |
Molecular Weight | 401.435 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[H][C@]12SCC(OC)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C3=CCC=CC3)C(O)=O
InChI
InChIKey=WDYHZZPITKKPTD-OEDJVVDHSA-N
InChI=1S/C16H19N3O5S.2H2O/c1-24-9-7-25-15-11(14(21)19(15)12(9)16(22)23)18-13(20)10(17)8-5-3-2-4-6-8;;/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23);2*1H2/t10-,11-,15-;;/m1../s1
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/6998373
Sources: http://www.ncbi.nlm.nih.gov/pubmed/6998373
Cefroxadine is an antibiotic developed for the treatment of bacterial infectious diseases caused by gram-negative and gram-positive organisms. The information about drug status is unavailable and is supposed to be "discontinued", however it may be manufactured in Italy by Novartis.
Originator
Approval Year
Sample Use Guides
The daily dosage of 1000mg should be divided into 2 fractions and should be taken after breakfast and after supper.
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/6998373
The spectrum of antibacterial activity of cefroxadine against gram-positive and gram-negative bacteria was studied. About 0.005 ml of diluted culture was inoculated by Micro-planter onto agar plates containing a series of serial twofold dilutions of a drug. The concentration of the drug required to inhibit the growth of 50% of the total number of tested E. coli strains (MIC50) was 3.13 to 6.25 ug/ml. The MIC50 of cefroxadine against K. pneumoniae strains was 3.13 to 6.25 ug/ml.
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439L36E61V
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23724961
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300000038931
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m3215
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DTXSID90241900
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95615-72-8
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SUBSTANCE RECORD