DESGLUGASTRIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C49H61N9O13
Molecular Weight	984.063
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C[C@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](C)NC(=O)CCCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC4=CC=CC=C4)C(N)=O

InChI

InChIKey=BRUVESZIOCJLDB-GJPUTSFASA-N

InChI=1S/C49H61N9O13/c1-27(2)20-36(47(69)58-39(24-43(64)65)49(71)55-35(44(50)66)21-29-10-5-4-6-11-29)57-48(70)38(23-31-25-51-34-13-8-7-12-33(31)34)54-41(61)26-52-46(68)37(22-30-16-18-32(59)19-17-30)56-45(67)28(3)53-40(60)14-9-15-42(62)63/h4-8,10-13,16-19,25,27-28,35-39,51,59H,9,14-15,20-24,26H2,1-3H3,(H2,50,66)(H,52,68)(H,53,60)(H,54,61)(H,55,71)(H,56,67)(H,57,70)(H,58,69)(H,62,63)(H,64,65)/t28-,35-,36-,37-,38-,39-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2600453 | https://www.ncbi.nlm.nih.gov/pubmed/2427345 | Elks, J. (2014) The Dictionary of Drugs, page 363, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Desglugastrin is a gastric acid secretion stimulator. It dose dependently stimulated gastric acid secretion in anaesthetized rats. In view of the trophic action of gastrointestinal hormones on the exocrine pancreas, the effects of desglugastrin on the growth of hamster pancreatic well differentiated adenocarcinoma were investigated in vitro. Desglugastrin exhibited the greatest effect on thymidine incorporation into these cells after a lag period of 96 h. Doses of desglugastrin caused a significant and dose-dependent increase in thymidine incorporation.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

100 ug/kg per hour

Route of Administration: Intravenous

Name

Type

Language

DIAGASTRIN

Preferred Name

English

DESGLUGASTRIN

Official Name

English

desglugastrin [INN]

Common Name

English

N-(4-CARBOXYBUTYRYL)-L-ALANYL-L-TYROSYLGLYCYL-L-TRYPTOPHYL-L-LEUCYL-L-.ALPHA.-ASPARTYLPHENYL-L-ALANINAMIDE

Common Name

English

L-PHENYLALANINAMIDE, N-(4-CARBOXY-1-OXOBUTYL)-L-ALANYL-L-TYROSYLGLYCYL-L-TRYPTOPHYL-L-LEUCYL-L-.ALPHA.-ASPARTYL-

Systematic Name

English

N-(4-CARBOXY-1-OXOBUTYL)-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C166715