Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H18N2O |
Molecular Weight | 278.3483 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)N1C(=O)N=C(C2=CC=CC=C2)C3=CC=C(C)C=C13
InChI
InChIKey=JTIGKVIOEQASGT-UHFFFAOYSA-N
InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3
Proquazon, a non-steroidal anti-inflammatory agent that was studied to use in the management of rheumatoid arthritis and osteoarthritis. The biochemical mechanism of action of proquazon via the inhibition of the core protein synthesis of proteoglycans and the secondary biosynthesis of the glucosamine.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0030166 Sources: https://www.ncbi.nlm.nih.gov/pubmed/442844 |
PubMed
Title | Date | PubMed |
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Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations. | 2003 Summer |
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High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine. | 2007 Jul-Aug |
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Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3297621
proquazone 300 to 900 mg/day
Route of Administration:
Oral
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NCI_THESAURUS |
C257
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WHO-ATC |
M01AX13
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WHO-VATC |
QM01AX13
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PROQUAZONE
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22760-18-5
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3176
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SUB10127MIG
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2311
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C011385
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100000080810
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C73093
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31508
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DTXSID4021210
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245-203-7
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m9254
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42VPJ2980S
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CHEMBL268501
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DB13649
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ACTIVE MOIETY