PROQUAZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N1C(=O)N=C(C2=CC=CC=C2)C3=CC=C(C)C=C13

InChI

InChIKey=JTIGKVIOEQASGT-UHFFFAOYSA-N

InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3297621 |https://www.ncbi.nlm.nih.gov/pubmed/442844

Proquazon, a non-steroidal anti-inflammatory agent that was studied to use in the management of rheumatoid arthritis and osteoarthritis. The biochemical mechanism of action of proquazon via the inhibition of the core protein synthesis of proteoglycans and the secondary biosynthesis of the glucosamine.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
proteoglycan biosynthetic process 3 Target ID: GO:0030166 Sources: https://www.ncbi.nlm.nih.gov/pubmed/442844	Inhibitor 8297

PubMed

Title	Date	PubMed
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.	2003 Jul	12770513
Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations.	2003 Summer	12835494
Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution.	2004 Dec 9	15541920
High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine.	2007 Jul-Aug	17760334
A peripatetic pediatrician's journey into pediatric rheumatology: Part II.	2007 Jun 21	17584931
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Patents

Sample Use Guides

In Vivo Use Guide

proquazone 300 to 900 mg/day

Route of Administration: Oral

Name

Type

Language

PROQUAZONE

Official Name

English

PROQUAZONE [MI]

Common Name

English

43-715

Code

English

Proquazone [WHO-DD]

Common Name

English

PROQUAZONE [MART.]

Common Name

English

1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone

Systematic Name

English

proquazone [INN]

Common Name

English

PROQUAZONE [USAN]

Common Name

English

PROQUAZONE [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257