Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H11NO3 |
| Molecular Weight | 145.1564 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CCCC=O)C(O)=O
InChI
InChIKey=GFXYTQPNNXGICT-YFKPBYRVSA-N
InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene. | 2001 Apr |
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| Loss of compartmentalization causes misregulation of lysine biosynthesis in peroxisome-deficient yeast cells. | 2002 Dec |
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| Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. | 2002 Dec 1 |
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| Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. | 2002 Jul 16 |
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| The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector. | 2002 Mar |
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| Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls. | 2002 Sep |
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| Effects of commonly consumed fruit juices and carbohydrates on redox status and anticancer biomarkers in female rats. | 2003 |
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| In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats. | 2003 Aug 27 |
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| Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity. | 2003 Aug 29 |
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| Histidine and lysine as targets of oxidative modification. | 2003 Dec |
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| Recent advances in the analysis of oxidized proteins. | 2003 Dec |
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| Personal PM2.5 exposure and markers of oxidative stress in blood. | 2003 Feb |
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| Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain. | 2003 Mar 7 |
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| Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats. | 2004 Aug |
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| Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells. | 2004 Mar |
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| Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain. | 2004 May |
|
| Posttranslational activation, site-directed mutation and phylogenetic analyses of the lysine biosynthesis enzymes alpha-aminoadipate reductase Lys1p (AAR) and the phosphopantetheinyl transferase Lys7p (PPTase) from Schizosaccharomyces pombe. | 2004 Nov |
|
| Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon. | 2004 Oct |
|
| Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. | 2005 Aug |
|
| In silico analysis of the adenylation domains of the freestanding enzymes belonging to the eucaryotic nonribosomal peptide synthetase-like family. | 2005 Feb |
|
| Study of plasma antioxidant status in Alzheimer's disease. | 2005 Jul |
|
| Formation of alpha-aminoadipic and gamma-glutamic semialdehydes in proteins by the maillard reaction. | 2005 Jun |
|
| Characterization of the oat1 gene of Penicillium chrysogenum encoding an omega-aminotransferase: induction by L-lysine, L-ornithine and L-arginine and repression by ammonium. | 2005 Oct |
|
| The lysine-ketoglutarate reductase-saccharopine dehydrogenase is involved in the osmo-induced synthesis of pipecolic acid in rapeseed leaf tissues. | 2006 Jul-Sep |
|
| Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat. | 2006 Nov |
|
| The effect of antioxidant supplementation on hepatitis C viral load, transaminases and oxidative status: a randomized trial among chronic hepatitis C virus-infected patients. | 2006 Sep |
|
| Alpha-aminoadipic semialdehyde is the biomarker for pyridoxine dependent epilepsy caused by alpha-aminoadipic semialdehyde dehydrogenase deficiency. | 2007 Aug |
|
| Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levels. | 2007 Aug |
|
| Site-specific formation of Maillard, oxidation, and condensation products from whey proteins during reaction with lactose. | 2007 Jul 25 |
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| The pediatric neurotransmitter disorders. | 2007 May |
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| An intriguing "silent" mutation and a founder effect in antiquitin (ALDH7A1). | 2007 Oct |
|
| Indoor particles affect vascular function in the aged: an air filtration-based intervention study. | 2008 Feb 15 |
|
| Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness. | 2008 Oct |
|
| Two novel ALDH7A1 (antiquitin) splicing mutations associated with pyridoxine-dependent seizures. | 2009 Apr |
|
| Fluorescent detection of alpha-aminoadipic and gamma-glutamic semialdehydes in oxidized proteins. | 2009 Mar 15 |
|
| Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. | 2009 May |
|
| Analysis of protein oxidation markers alpha-aminoadipic and gamma-glutamic semialdehydes in food proteins using liquid chromatography (LC)-electrospray ionization (ESI)-multistage tandem mass spectrometry (MS). | 2009 May 13 |
|
| Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. | 2009 Oct 30 |
|
| Analysis of protein carbonyls in meat products by using the DNPH-method, fluorescence spectroscopy and liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS). | 2009 Sep |
|
| Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice. | 2010 |
|
| A targeted mass spectrometry-based approach for the identification and characterization of proteins containing α-aminoadipic and γ-glutamic semialdehyde residues. | 2010 Dec |
|
| The EEG response to pyridoxine-IV neither identifies nor excludes pyridoxine-dependent epilepsy. | 2010 Dec |
|
| A multidisciplinary study of archaeological grape seeds. | 2010 Feb |
|
| Metabolism of lysine in alpha-aminoadipic semialdehyde dehydrogenase-deficient fibroblasts: evidence for an alternative pathway of pipecolic acid formation. | 2010 Jan 4 |
|
| Neonatal vitamin-responsive epileptic encephalopathies. | 2010 Jan-Feb |
|
| Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency). | 2010 Jul |
|
| Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. | 2010 Jun 11 |
|
| Finding new enzymes from bacterial physiology: a successful approach illustrated by the detection of novel oxidases in Marinomonas mediterranea. | 2010 Mar 5 |
|
| The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1. | 2010 Oct |
|
| Human antiquitin: structural and functional studies. | 2011 May 30 |
Patents
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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6665-12-9
Created by
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1962-83-0
Created by
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DB02571
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425I4Y24YZ
Created by
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SUB197078
Created by
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DTXSID00862802
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17917
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Allysine
Created by
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57988
Created by
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100000182788
Created by
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17027
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C000061
Created by
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160603
Created by
admin on Fri Dec 15 18:30:29 GMT 2023 , Edited by admin on Fri Dec 15 18:30:29 GMT 2023
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SUBSTANCE RECORD
